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Optical clearing agents based on metallic and dielectric nanoparticles for caries diagnostic by optical coherence tomography.
Carneiro, Vanda Sanderana Macedo; de Melo, Eloiza Leonardo; de Oliveira Mota, Claudia Cristina Brainer; da Silva, Evair Josino; da Silva, Andréa Ferreira; Deama, Nathalia Seimi; Miranda, Jéssica Meirinhos; da Rocha, Suzanne Ivila Santos; de Lima Pires, Caio; Gomes, Anderson Stevens Leonidas; de Martínez Gerbi, Marleny Elizabeth Márquez.
Afiliação
  • Carneiro VSM; Graduate Program in Dentistry, Universidade de Pernambuco (PPGO-UPE), Recife, Brazil.
  • de Melo EL; Graduate Program in Dentistry, Universidade de Pernambuco (PPGO-UPE), Recife, Brazil. eloiza.leonardo@upe.br.
  • de Oliveira Mota CCB; Dental School of Pernambuco, Universidade de Pernambuco Campus Arcoverde, Arcoverde, PE, Brazil.
  • da Silva EJ; Dental School, Centro Universitário Tabosa de Almeida, Caruaru, PE, Brazil.
  • da Silva AF; Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Deama NS; Graduate Program in Materials Science, Universidade Federal de Pernambuco, Recife, PE, Brazil.
  • Miranda JM; Graduate Program in Dentistry, Universidade de Pernambuco (PPGO-UPE), Recife, Brazil.
  • da Rocha SIS; Graduate Program in Dentistry, Universidade de Pernambuco (PPGO-UPE), Recife, Brazil.
  • de Lima Pires C; Graduate Program in Dentistry, Universidade de Pernambuco (PPGO-UPE), Recife, Brazil.
  • Gomes ASL; Graduate Program in Dentistry, Universidade de Pernambuco (PPGO-UPE), Recife, Brazil.
  • de Martínez Gerbi MEM; Graduate Program in Dentistry, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Clin Oral Investig ; 28(1): 72, 2024 Jan 04.
Article em En | MEDLINE | ID: mdl-38175293
ABSTRACT

OBJECTIVE:

This study aimed to assess the effect of titanium dioxide (TiO2) and silver (Ag) nanoparticles dispersed in glycerol or water, serving as optical clearing agents nanocolloids (OCAs-NC), for improving optical coherence tomography (OCT) images and highlighting incipient lesions in ex vivo human teeth. MATERIALS AND

METHODS:

Twelve human teeth with incipient lesions were divided into seven groups according to the OCA-NC; they were subjected to G1 (air), G2 (glycerol), G3 (TiO2 0.1%), G4 (TiO2 0.01%), G5 (TiO2 0.001%), G6 (AgNO3 10%), and G7 (AgNO3 100%). The OCA-NC was applied to the occlusal surface, and two-dimensional images of the specimens were analyzed using OCT (930 nm central wavelength; 100 nm bandwidth; 5 mW output power; axial resolution of 7/5.3 µm in water and air, respectively; lateral resolution of 8 µm; and light penetration depth of 1.6 mm inside the sample).

RESULTS:

The findings demonstrated that the utilization of OCAs-NC containing metallic or dielectric nanoparticles (AgNO3 and TiO2) led to improved differentiation between sound and demineralized enamel on occlusal surfaces. Additionally, it enhanced the depth of image penetration when analyzing this hard tissue with OCT. CLINICAL RELEVANCE In the current context of minimally invasive dentistry, the use of OCAs-NC in conjunction with OCT can provide clinicians with early diagnosis, allowing for the determination of less/more invasive therapies and consequently halting the disease before cavitation of dental tissues occurs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cárie Dentária / Nanopartículas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cárie Dentária / Nanopartículas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha