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Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations.
Pinto, Thalyta Nery Carvalho; da Silva, Cibele Cristine Berto Marques; Pinto, Regina Maria Carvalho; da Silva Duarte, Alberto José; Benard, Gil; Fernandes, Juliana Ruiz.
Afiliação
  • Pinto TNC; Laboratory of Dermatology and Immunodeficiencies (LIM56), Faculdade de Medicina, Tropical Medicine Institute, Universidade de São Paulo, Av. Dr. Arnaldo, São Paulo, 455, Brazil.
  • da Silva CCBM; Department of Physical Therapy, School of Medicine, São Paulo University, R. Dr. Ovídio Pires de Campos, São Paulo, 255, Brazil.
  • Pinto RMC; Pulmonary Department, Heart Institute (InCor), School of Medicine, São Paulo University, Av. Dr. Enéas de Carvalho Aguiar, São Paulo, 44, Brazil.
  • da Silva Duarte AJ; Laboratory of Dermatology and Immunodeficiencies (LIM56), Faculdade de Medicina, Tropical Medicine Institute, Universidade de São Paulo, Av. Dr. Arnaldo, São Paulo, 455, Brazil.
  • Benard G; Laboratory of Dermatology and Immunodeficiencies (LIM56), Faculdade de Medicina, Tropical Medicine Institute, Universidade de São Paulo, Av. Dr. Arnaldo, São Paulo, 455, Brazil.
  • Fernandes JR; Laboratory of Dermatology and Immunodeficiencies (LIM56), Faculdade de Medicina, Tropical Medicine Institute, Universidade de São Paulo, Av. Dr. Arnaldo, São Paulo, 455, Brazil. fruiz.juliana@usp.br.
Geroscience ; 46(2): 2729-2738, 2024 04.
Article em En | MEDLINE | ID: mdl-38157147
ABSTRACT
Several disturbances in T-cell mediated immunity have been described during aging, but immunosenescence of the B-cell compartment is less well elucidated. The peripheral blood B-cell compartment (CD19+) can be split into six main subpopulations according to the cell surface markers IgD, CD27, CD24, and CD38 Transitional, naïve, unswitched, switched, double negative and plasmablasts. We thus aimed to verify whether shifts in these subsets occur during healthy and pathological aging. We recruited three groups of aged people (> 60 years old), healthy, COPD patients, and smokers without altered pulmonary function test, and a fourth group of individuals 18-40 years old (youngs). Total B-cells percentage and absolute number were similar among the healthy aged, COPD patients, and youngs, but the smokers showed significantly higher absolute numbers. While all six B-cell subset percentages were comparable among the healthy aged, COPD patients, and youngs, smokers showed significantly higher percentages of switched B-cells and reduced naïve B-cells than the other three groups, resulting in an inverted naiveswitched ratio. Analysis of the cell subset absolute numbers showed a similar trend. Overall, our results suggest that aging drives milder alterations in the distribution of peripheral blood B-cell subpopulations than in the T-cell compartment. We suggest that it is the T-cell immunosenescence that most contributes to the poor humoral immune responses in the elderly, vaccine responses included. Surprisingly it was the smokers who showed significant alterations when compared with the youngs, healthy aged, and aged COPD patients, probably as a result of the chronic immune stimulation described in active smoking subjects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos B / Doença Pulmonar Obstrutiva Crônica Limite: Aged / Humans Idioma: En Revista: Geroscience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos B / Doença Pulmonar Obstrutiva Crônica Limite: Aged / Humans Idioma: En Revista: Geroscience Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça