Your browser doesn't support javascript.
loading
Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community.
Anjos, Rosângela O; Portilho, Moyra M; Jacob-Nascimento, Leile Camila; Carvalho, Caroline X; Moreira, Patrícia S S; Sacramento, Gielson A; Nery Junior, Nivison R R; de Oliveira, Daiana; Cruz, Jaqueline S; Cardoso, Cristiane W; Argibay, Hernan D; Plante, Kenneth S; Plante, Jessica A; Weaver, Scott C; Kitron, Uriel D; Reis, Mitermayer G; Ko, Albert I; Costa, Federico; Ribeiro, Guilherme S.
Afiliação
  • Anjos RO; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Portilho MM; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Jacob-Nascimento LC; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Carvalho CX; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Moreira PSS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Sacramento GA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Nery Junior NRR; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • de Oliveira D; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil.
  • Cruz JS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Cardoso CW; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Argibay HD; Secretaria Municipal de Saúde de Salvador, Salvador, Brazil.
  • Plante KS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Plante JA; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil.
  • Weaver SC; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
  • Kitron UD; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
  • Reis MG; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America.
  • Ko AI; Emory University, Atlanta, Georgia, United States of America.
  • Costa F; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
  • Ribeiro GS; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil.
PLoS Negl Trop Dis ; 17(12): e0011863, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38150470
ABSTRACT

BACKGROUND:

The first chikungunya virus (CHIKV) outbreaks during the modern scientific era were identified in the Americas in 2013, reaching high attack rates in Caribbean countries. However, few cohort studies have been performed to characterize the initial dynamics of CHIKV transmission in the New World. METHODOLOGY/PRINCIPAL

FINDINGS:

To describe the dynamics of CHIKV transmission shortly after its introduction in Brazil, we performed semi-annual serosurveys in a long-term community-based cohort of 652 participants aged ≥5 years in Salvador, Brazil, between Feb-Apr/2014 and Nov/2016-Feb/2017. CHIKV infections were detected using an IgG ELISA. Cumulative seroprevalence and seroincidence were estimated and spatial aggregation of cases was investigated. The first CHIKV infections were identified between Feb-Apr/2015 and Aug-Nov/2015 (incidence 10.7%) and continued to be detected at low incidence in subsequent surveys (1.7% from Aug-Nov/2015 to Mar-May/2016 and 1.2% from Mar-May/2016 to Nov/206-Feb/2017). The cumulative seroprevalence in the last survey reached 13.3%. It was higher among those aged 30-44 and 45-59 years (16.1% and 15.6%, respectively), compared to younger (12.4% and 11.7% in <15 and 15-29 years, respectively) or older (10.3% in ≥60 years) age groups, but the differences were not statistically significant. The cumulative seroprevalence was similar between men (14.7%) and women (12.5%). Yet, among those aged 15-29 years, men were more often infected than women (18.1% vs. 7.4%, respectively, P = 0.01), while for those aged 30-44, a non-significant opposite trend was observed (9.3% vs. 19.0%, respectively, P = 0.12). Three spatial clusters of cases were detected in the study site and an increased likelihood of CHIKV infection was detected among participants who resided with someone with CHIKV IgG antibodies. CONCLUSIONS/

SIGNIFICANCE:

Unlike observations in other settings, the initial spread of CHIKV in this large urban center was limited and focal in certain areas, leaving a high proportion of the population susceptible to further outbreaks. Additional investigations are needed to elucidate the factors driving CHIKV spread dynamics, including understanding differences with respect to dengue and Zika viruses, in order to guide prevention and control strategies for coping with future outbreaks.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Febre de Chikungunya / Zika virus / Infecção por Zika virus Limite: Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Febre de Chikungunya / Zika virus / Infecção por Zika virus Limite: Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos