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Distribution of blaCTX-M-gene variants in E. coli from different origins in Ecuador.
Valenzuela, Xavier; Hedman, Hayden; Villagomez, Alma; Cardenas, Paul; Eisenberg, Joseph N S; Levy, Karen; Zhang, Lixin; Trueba, Gabriel.
Afiliação
  • Valenzuela X; Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador.
  • Hedman H; Facultad de Medicina, Universidad de la Americas (UDLA), Quito, Ecuador.
  • Villagomez A; School for Environment and Sustainability, University of Michigan, Ann Arbor, MI, 48109, United States.
  • Cardenas P; Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador.
  • Eisenberg JNS; Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador.
  • Levy K; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, United States.
  • Zhang L; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States.
  • Trueba G; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, 48824, United States.
Med Microecol ; 182023 Dec.
Article em En | MEDLINE | ID: mdl-38148908
ABSTRACT
The increasing abundance of extended spectrum (ß-lactamase (ESBL) genes in E. coli, and other commensal and pathogenic bacteria, endangers the utility of third or more recent generation cephalosporins, which are major tools for fighting deadly infections. The role of domestic animals in the transmission of ESBL carrying bacteria has been recognized, especially in low- and middle-income countries, however the horizontal gene transfer of these genes is difficult to assess. Here we investigate blaCTX-M gene diversity (and flanking nucleotide sequences) in E. coli from chicken and humans, in an Ecuadorian rural community and from chickens in another location in Ecuador. The blaCTX-M associated sequences in isolates from humans and chickens in the same remote community showed greater similarity than those found in E. coli in a chicken industrial operation 200 km away. Our study may provide evidence of blaCTX-M transfer between chickens and humans in the community.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Med Microecol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Med Microecol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Equador País de publicação: Holanda