Your browser doesn't support javascript.
loading
Environmental enrichment changes the effects of prenatal and postnatal undernutrition on memory, anxiety traits, Bdnf and TrkB expression in the hippocampus of male adult rats.
Lima, Odair José Farias; Ribeiro, Juliana da Silva; Vasconcelos, Jefferson Diego Costa; Ferraz, Marília Freire Isidro; Silva, Caroline Emiliane de Melo Tavares da Rosa E; Barros, Waleska Maria Almeida; Vieira, Gilberto Ramos; David, Mírian Celly Medeiros Miranda; Matos, Rhowena Jane Barbosa.
Afiliação
  • Lima OJF; Physical Education and Sports Science Nucleus, Academic Center of Vitória, Federal University of Pernambuco, Brazil.
  • Ribeiro JDS; Nutrition Nucleus, Academic Center of Vitória, Federal University of Pernambuco, Brazil.
  • Vasconcelos JDC; Physical Education and Sports Science Nucleus, Academic Center of Vitória, Federal University of Pernambuco, Brazil.
  • Ferraz MFI; Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Pernambuco, Brazil.
  • Silva CEMTDRE; Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Pernambuco, Brazil.
  • Barros WMA; Multicenter Postgraduate Program in Physiological Sciences, Academic Center of Vitória, Federal University of Pernambuco, Brazil.
  • Vieira GR; Postgraduate Program in Physical Education, Health Sciences Center, Federal University of Pernambuco, Brazil.
  • David MCMM; Postgraduate Program in Neuropsychiatry and Behavioural Sciences, Federal University of Pernambuco, Brazil.
  • Matos RJB; Health Sciences Center, Federal University of Recôncavo of Bahia, Brazil. Electronic address: rhowena.matos@ufrb.edu.br.
Behav Brain Res ; 460: 114817, 2024 03 05.
Article em En | MEDLINE | ID: mdl-38122904
ABSTRACT
Environmental factors such as undernutrition and environmental enrichment can promote changes in the molecular and behavioural mechanisms related to cognition. Herein, we investigated the effect of enriched environment stimulation in rats that were malnourished in the pre- and postnatal periods on changes in the gene expression of brain-derived neurotrophic factor and its receptor in the hippocampus, as well as on anxiety traits and memory. Early undernutrition promoted weight reduction, increased the risk analysis, reduced permanence in the open arm of the elevated plus-maze and induced a reduction in the gene expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B. However, exposure to an enriched environment from 30 to 90 days' old maintained the malnourished phenotype, leading to weight reduction in the control group. In addition, the enriched environment did not alter the risk assessment in the undernourished group, but it did increase the frequency of labyrinth entries. Sixty-day exposure to the enriched environment resulted in a reversal in the gene expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the hippocampus of malnourished rats and favoured of long-term memory in the object recognition test in the open-field. These results suggest that an enriched environment may have a protective effect in adult life by inducing changes in long-term memory and anxiety traits in animals that were undernourished in early life. Furthermore, reversing these effects of undernutrition involves mechanisms linked to the molecular signalling of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the hippocampus.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Desnutrição Limite: Animals / Pregnancy Idioma: En Revista: Behav Brain Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Desnutrição Limite: Animals / Pregnancy Idioma: En Revista: Behav Brain Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda