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A network-based approach to understanding gene-biological processes affecting economically important traits of Nelore cattle.
Corrêa, Mariely Simone Lopes; Silva, Evandro Neves; Dos Santos, Thaís Cristina Ferreira; Simielli Fonseca, Larissa Fernanda; Magalhães, Ana Fabrícia Braga; Verardo, Lucas Lima; de Albuquerque, Lucia Galvão; Silva, Danielly Beraldo Dos Santos.
Afiliação
  • Corrêa MSL; Professor Edson Antônio Velano University (UNIFENAS), Alfenas, Minas Gerais, Brazil.
  • Silva EN; Professor Edson Antônio Velano University (UNIFENAS), Alfenas, Minas Gerais, Brazil.
  • Dos Santos TCF; Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.
  • Simielli Fonseca LF; Professor Edson Antônio Velano University (UNIFENAS), Alfenas, Minas Gerais, Brazil.
  • Magalhães AFB; National Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
  • Verardo LL; School of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
  • de Albuquerque LG; Department of Animal Science, Federal University of Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
  • Silva DBDS; Department of Animal Science, Federal University of Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
Anim Genet ; 55(1): 55-65, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38112158
ABSTRACT
This study aimed to build gene-biological process networks with differentially expressed genes associated with economically important traits of Nelore cattle from 17 previous studies. The genes were clustered into three groups by evaluated traits group 1, production traits; group 2, carcass traits; and group 3, meat quality traits. For each group, a gene-biological process network analysis was performed with the differentially expressed genes in common. For production traits, 37 genes were found in common, of which 13 genes were enriched for six Gene Ontology (GO) terms; these terms were not functionally grouped. However, the enriched GO terms were related to homeostasis, the development of muscles and the immune system. For carcass traits, four genes were found in common. Thus, it was not possible to functionally group these genes into a network. For meat quality traits, the analysis revealed 222 genes in common. CSRP3 was the only gene differentially expressed in all three groups. Non-redundant biological terms for clusters of genes were functionally grouped networks, reflecting the cross-talk between all biological processes and genes involved. Many biological processes and pathways related to muscles, the immune system and lipid metabolism were enriched, such as striated muscle cell development and triglyceride metabolic processes. This study provides insights into the genetic mechanisms of production, carcass and meat quality traits of Nelore cattle. This information is fundamental for a better understanding of the complex traits and could help in planning strategies for the production and selection systems of Nelore cattle.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Redes Reguladoras de Genes / Carne Limite: Animals Idioma: En Revista: Anim Genet Assunto da revista: GENETICA / MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Redes Reguladoras de Genes / Carne Limite: Animals Idioma: En Revista: Anim Genet Assunto da revista: GENETICA / MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido