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Basal Forebrain Modulation of Olfactory Coding In Vivo.
Venegas, Juan Pablo; Navarrete, Marcela; Orellana-Garcia, Laura; Rojas, Marcelo; Avello-Duarte, Felipe; Nunez-Parra, Alexia.
Afiliação
  • Venegas JP; Physiology Laboratory, Biology Department, Faculty of Science, University of Chile, Chile. Universidad de Chile University of Chile Chile.
  • Navarrete M; Physiology Laboratory, Biology Department, Faculty of Science, University of Chile, Chile. Universidad de Chile University of Chile Chile.
  • Orellana-Garcia L; Physiology Laboratory, Biology Department, Faculty of Science, University of Chile, Chile. Universidad de Chile University of Chile Chile.
  • Rojas M; Physiology Laboratory, Biology Department, Faculty of Science, University of Chile, Chile. Universidad de Chile University of Chile Chile.
  • Avello-Duarte F; Physiology Laboratory, Biology Department, Faculty of Science, University of Chile, Chile. Universidad de Chile University of Chile Chile.
  • Nunez-Parra A; Physiology Laboratory, Biology Department, Faculty of Science, University of Chile, Chile. Universidad de Chile University of Chile Chile.
Int J Psychol Res (Medellin) ; 16(2): 62-86, 2023.
Article em En | MEDLINE | ID: mdl-38106956
ABSTRACT
Sensory perception is one of the most fundamental brain functions, allowing individuals to properly interact and adapt to a constantly changing environment. This process requires the integration of bottom-up and topdown neuronal activity, which is centrally mediated by the basal forebrain, a brain region that has been linked to a series of cognitive processes such as attention and alertness. Here, we review the latest research using optogenetic approaches in rodents and in vivo electrophysiological recordings that are shedding light on the role of this region, in regulating olfactory processing and decisionmaking. Moreover, we summarize evidence highlighting the anatomical and physiological differences in the basal forebrain of individuals with autism spectrum disorder, which could underpin the sensory perception abnormalities they exhibit, and propose this research line as a potential opportunity to understand the neurobiological basis of this disorder.
RESUMEN
La percepción sensorial es una de las funciones cerebrales más fundamentales, permitiendo a los individuos interactuar de manera apropiada con el entorno y adaptarse a un ambiente en constante cambio. Este proceso requiere la integración de la actividad neuronal ascendente y descendente, que es mediada por el cerebro basal (BF), una región cerebral que ha sido asociada a una serie de procesos cognitivos, como estados de atención y alerta.En este trabajo revisamos las últimas investigaciones que han utilizado optogenética y registros electrofisiológicos in vivo que han iluminado el rol del BF en el procesamiento olfatorio y la toma de decisiones. Además, resumimos la literatura que destaca las alteraciones fisiológicas y anatómicas del BF de individuos con trastornos del espectro autista, que podrían subyacer las anormalidades en la percepción que presentan, y proponemos esta línea de investigación como una posible oportunidad para entender las bases neurobiológicas de este trastorno.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Psychol Res (Medellin) Ano de publicação: 2023 Tipo de documento: Article País de publicação: Colômbia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Psychol Res (Medellin) Ano de publicação: 2023 Tipo de documento: Article País de publicação: Colômbia