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White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer's disease continuum.
Hirschfeld, Lauren R; Deardorff, Rachael; Chumin, Evgeny J; Wu, Yu-Chien; McDonald, Brenna C; Cao, Sha; Risacher, Shannon L; Yi, Dahyun; Byun, Min Soo; Lee, Jun-Young; Kim, Yu Kyeong; Kang, Koung Mi; Sohn, Chul-Ho; Nho, Kwangsik; Saykin, Andrew J; Lee, Dong Young.
Afiliação
  • Hirschfeld LR; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pricelr@iu.edu.
  • Deardorff R; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pricelr@iu.edu.
  • Chumin EJ; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Wu YC; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • McDonald BC; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Cao S; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
  • Risacher SL; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Yi D; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Byun MS; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Lee JY; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Kim YK; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Kang KM; Department of Biostatistics and Health Data Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Sohn CH; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Nho K; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Saykin AJ; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, 03080, South Korea.
  • Lee DY; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 03080, South Korea.
Alzheimers Res Ther ; 15(1): 218, 2023 12 16.
Article em En | MEDLINE | ID: mdl-38102714
ABSTRACT

BACKGROUND:

White matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimer's disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations.

METHODS:

We assessed the relationship between CBH WM integrity and cognition or amyloid burden in 505 Korean older adults aged ≥ 55 years, including 276 cognitively normal older adults (CN), 142 with mild cognitive impairment (MCI), and 87 AD patients, recruited as part of the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) at Seoul National University.

RESULTS:

Compared to CN, AD and MCI subjects showed significantly higher RD, MD, and AxD values (all p-values < 0.001) and significantly lower FA values (left p ≤ 0.002, right p ≤ 0.015) after Bonferroni adjustment for multiple comparisons. Most tests of cognition and mood (p < 0.001) as well as higher medial temporal amyloid burden (p < 0.001) were associated with poorer WM integrity in the CBH after Bonferroni adjustment.

CONCLUSION:

These findings are consistent with patterns of WM microstructural damage previously reported in non-Hispanic White (NHW) MCI/AD cohorts, reinforcing existing evidence from predominantly NHW cohort studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva / Substância Branca Limite: Aged / Humans País/Região como assunto: Asia Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva / Substância Branca Limite: Aged / Humans País/Região como assunto: Asia Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido