Varicocele and testicular cord torsion: immune testicular microenvironment imbalance.

Guazzone, Vanesa A; Lustig, Livia

Guazzone, Vanesa A; Lustig, Livia.

Afiliação

Guazzone VA; Universidad de Buenos Aires, Facultad de Medicina, Departamento de Biología Celular e Histología/Unidad Académica II, Buenos Aires, Argentina.
Lustig L; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad de Buenos Aires, Instituto de Investigaciones Biomédicas (INBIOMED), Buenos Aires, Argentina.

Front Cell Dev Biol ; 11: 1282579, 2023.

Article em En | MEDLINE | ID: mdl-38099296

ABSTRACT

ABSTRACT

The main functions of the testis, steroidogenesis and spermatogenesis, depend on the endocrine axis and systemic and local tolerance mechanisms. Infectious or non-infectious diseases may disturb testicular immune regulation causing infertility. Literature has illustrated that bacterial and viral infections lead to autoimmune infertility either sperm antibodies or autoimmune epidydimo-orchitis. However, little is known about the association between non-infectious testicular pathologic diseases and autoimmunity. Here we review the novel aspect of varicocele and testicular cord torsion pathology linked to inflammation and discuss how immune factors could contribute to or modulate autoimmunity in ipsi- and contralateral testis.

Palavras-chave

autoimmunity; infertility; testicular cord torsion; testicular inflammation; testis; varicocele

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Cell Dev Biol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google