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Window therapeutic of extraoral photobiomodulation for prevention of oral mucositis in HSCT patients: additional arm.
da Cruz Santos, Letícia Beatriz; Ramos-Pinto, Mariana Bitu; Zerbato, Rodolfo Maestrello; Ferreira, Maria Emilia Mota Galdino; Schmidt-Filho, Jayr; Martins, Manoela Domingues; Alves, Fabio Abreu.
Afiliação
  • da Cruz Santos LB; Stomatology Department, A.C. Camargo Cancer Center, R: Prof. Antônio Prudente, 211, Bairro: Liberdade, São Paulo, 01509-900, Brazil.
  • Ramos-Pinto MB; Stomatology Department, A.C. Camargo Cancer Center, R: Prof. Antônio Prudente, 211, Bairro: Liberdade, São Paulo, 01509-900, Brazil.
  • Zerbato RM; Stomatology Department, A.C. Camargo Cancer Center, R: Prof. Antônio Prudente, 211, Bairro: Liberdade, São Paulo, 01509-900, Brazil.
  • Ferreira MEMG; Stomatology Department, A.C. Camargo Cancer Center, R: Prof. Antônio Prudente, 211, Bairro: Liberdade, São Paulo, 01509-900, Brazil.
  • Schmidt-Filho J; Hematology Department, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Martins MD; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Alves FA; Stomatology Department, A.C. Camargo Cancer Center, R: Prof. Antônio Prudente, 211, Bairro: Liberdade, São Paulo, 01509-900, Brazil. falves@accamargo.org.br.
Support Care Cancer ; 32(1): 27, 2023 Dec 15.
Article em En | MEDLINE | ID: mdl-38097854
ABSTRACT

PURPOSE:

This study aimed to evaluate the efficacy of 1W extraoral photobiomodulation (EOPBM) and to compare with our previous results of 2W EOPBM and intraoral photobiomodulation (IOPBM) protocols in the management of oral mucositis (OM) related to hematopoietic stem cell transplantation (HSCT).

METHODS:

A total of 30 patients underwent autologous or allogenic HSCT. Experimental protocol of 1W EOPBM was performed daily beginning in the first day of the conditioning regimen until 5 days after transplantation. The application areas included six points on the face and three points on the cervical area. Additional application of IOPBM was performed if patients had ulcered mucositis. Its severity was assessed daily according to WHO (World Health Organization) and NCI (National Cancer Institute) scales. Oral and oropharynx pains were scored daily by visual analogue scale (VAS).

RESULTS:

The 1W EOPBM protocol was well tolerated without any complaints. Of total, 13 patients were male and 17 were female and the mean age was 49.3 years old. Most patients (21 patients - 70%) received autologous HSCT, and 24 patients (80%) underwent myeloablative conditioning (MAC) regime and 6 patients (20%) reduced intensive conditioning regime. Nineteen patients (63.3%) developed OM according to WHO criteria, 3 patients grade I, 10 grade II and 6 grade III. NCI mucositis grades were similar to WHO grades. OM outcomes of 1W EOPBM were similar when compared to our previous groups and no significant differences were observed. No differences were found between pain and the protocols (1W EOPBM, IOPBM and 2W EOPBM).

CONCLUSION:

This 1W EOPBM protocol seemed to be as effective as IOPBM and 2W EOPBM in the prevention of OM in HSCT patients. In addition, we might assume that there is a window of application on EOPBM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estomatite / Transplante de Células-Tronco Hematopoéticas / Terapia com Luz de Baixa Intensidade / Mucosite Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Assunto da revista: NEOPLASIAS / SERVICOS DE SAUDE Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estomatite / Transplante de Células-Tronco Hematopoéticas / Terapia com Luz de Baixa Intensidade / Mucosite Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Assunto da revista: NEOPLASIAS / SERVICOS DE SAUDE Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha