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PROGNOSTIC FACTORS OF LIVER TRANSPLANTATION FOR ACUTE-ON-CHRONIC LIVER FAILURE.
Cronst, Jane; Prediger, Lucas; Pinto, Marcelo Abreu; Ferraz, Julia; Mattos, Angelo Zamban de; Alvares-DA-Silva, Mario Reis; Kruel, Cleber Rosito Pinto; Chedid, Marcio Fernandes.
Afiliação
  • Cronst J; Universidade Federal do Rio Grande do Sul, Porto Alegre University Hospital, Graduate Program in Surgical Sciences - Porto Alegre (RS), Brazil.
  • Prediger L; Universidade Federal do Rio Grande do Sul, Porto Alegre University Hospital, Hepatobiliary Surgery and Liver Transplantation Unit - Porto Alegre (RS), Brazil.
  • Pinto MA; Feevale School of Medicine, Medical Sciences - Novo Hamburgo (RS), Brazil.
  • Ferraz J; Feevale School of Medicine, Medical Sciences - Novo Hamburgo (RS), Brazil.
  • Mattos AZ; Santa Casa Hospital Complex - Porto Alegre (RS), Brazil.
  • Alvares-DA-Silva MR; Universidade Federal do Rio Grande do Sul, Porto Alegre University Hospital, Hepatobiliary Surgery and Liver Transplantation Unit - Porto Alegre (RS), Brazil.
  • Kruel CRP; Universidade Federal do Rio Grande do Sul, Porto Alegre University Hospital, Hepatobiliary Surgery and Liver Transplantation Unit - Porto Alegre (RS), Brazil.
  • Chedid MF; Universidade Federal do Rio Grande do Sul, Porto Alegre University Hospital, Hepatobiliary Surgery and Liver Transplantation Unit - Porto Alegre (RS), Brazil.
Arq Bras Cir Dig ; 36: e1779, 2023.
Article em En | MEDLINE | ID: mdl-38088725
BACKGROUND: Liver transplantation (LT) is the only treatment that can provide long-term survival for patients with acute-on-chronic liver failure (ACLF). Although several studies identify prognostic factors for patients in ACLF who do not undergo LT, there is scarce literature about prognostic factors after LT in this population. AIM: Evaluate outcomes of ACLF patients undergoing LT, studying prognostic factors related to 1-year and 90 days post-LT. METHODS: Patients with ACLF undergoing LT between January 2005 and April 2021 were included. Variables such as chronic liver failure consortium (CLIF-C) ACLF values and ACLF grades were compared with the outcomes. RESULTS: The ACLF survival of patients (n=25) post-LT at 90 days, 1, 3, 5 and 7 years, was 80, 76, 59.5, 54.1 and 54.1% versus 86.3, 79.4, 72.6, 66.5 and 61.2% for patients undergoing LT for other indications (n=344), (p=0.525). There was no statistical difference for mortality at 01 year and 90 days among patients with the three ACLF grades (ACLF-1 vs. ACLF-2 vs. ACLF-3) undergoing LT, as well as when compared to non-ACLF patients. CLIF-C ACLF score was not related to death outcomes. None of the other studied variables proved to be independent predictors of mortality at 90 days, 1 year, or overall. CONCLUSIONS: LT conferred long-term survival to most transplant patients. None of the studied variables proved to be a prognostic factor associated with post-LT survival outcomes for patients with ACLF. Additional studies are recommended to clarify the prognostic factors of post-LT survival in patients with ACLF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Doença Hepática Terminal / Insuficiência Hepática Crônica Agudizada Limite: Humans Idioma: En Revista: Arq Bras Cir Dig Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Doença Hepática Terminal / Insuficiência Hepática Crônica Agudizada Limite: Humans Idioma: En Revista: Arq Bras Cir Dig Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil