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Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers.
Rayatpour, Atefeh; Radahmadi, Maryam; Izadi, Mina S; Ghasemi, Maedeh.
Afiliação
  • Rayatpour A; Isfahan University of Medical Sciences, Department of Physiology, School of Medicine, Hezar Jerib street, Isfahan, Iran.
  • Radahmadi M; Isfahan University of Medical Sciences, Department of Physiology, School of Medicine, Hezar Jerib street, Isfahan, Iran.
  • Izadi MS; Isfahan University of Medical Sciences, Department of Physiology, School of Medicine, Hezar Jerib street, Isfahan, Iran.
  • Ghasemi M; Isfahan University of Medical Sciences, Department of Physiology, School of Medicine, Hezar Jerib street, Isfahan, Iran.
An Acad Bras Cienc ; 95(4): e20200221, 2023.
Article em En | MEDLINE | ID: mdl-38088701
CRH neurons are found in the paraventricular nucleus(PVN) and central amygdala(CeA) nuclei. This study investigated the effects of sub-chronic CRH administration into the PVN and CeA nuclei on food intake biomarkers in rats divided into five groups: control, two shams, and two CRH-PVN and CRH-CeA groups(receiving CRH in nuclei for seven days). The CRH-PVN group had significantly higher cumulative food intake and food intake trends than the CRH-CeA group. The CRH-CeA and CRH-PVN groups exhibited significant increases in food intake during hours 1 and 2, respectively. Moreover, to be time-dependent, food intake is modulated by different brain nuclei. The CRH signaling pathway appeared to be activated later in the PVN than CeA. Both groups exhibited significantly higher leptin levels, the CRH-PVN group exhibited higher ghrelin levels and lower glucose levels. Repetitive administration of CRH into the PVN and CeA significantly reduced body weight differences. CRH administration into the PVN affected both leptin and ghrelin levels, but ghrelin had a greater impact on glucose variations and cumulative food intake than leptin. Finally, CRH administration into the PVN and CeA likely activated the HPA axis, and the CeA had a greater impact on the stress circuit than on food intake behavior.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Liberador da Corticotropina / Núcleo Central da Amígdala Limite: Animals Idioma: En Revista: An Acad Bras Cienc Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Liberador da Corticotropina / Núcleo Central da Amígdala Limite: Animals Idioma: En Revista: An Acad Bras Cienc Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil