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Renal protective effect of ellipticine against streptozotocin induced diabetic nephropathy in rats via suppression of oxidative stress and inflammatory mediator.
Li, Jun; Xie, Yu; Sun, Jimei; Bai, Fan; Hussain, Shaik Althaf; Gangireddygari, Venkata Subba Reddy; Jiang, Xiaolan.
Afiliação
  • Li J; The First People's Hospital of Yunnan Province - Department of Nephrology - The Affiliated Hospital of Kunming University of Science and Technology - Kunming - China.
  • Xie Y; The First People's Hospital of Yunnan Province - Department of Nephrology - The Affiliated Hospital of Kunming University of Science and Technology - Kunming - China.
  • Sun J; The First People's Hospital of Kunming - Department of Nephrology - Kunming - China.
  • Bai F; The First People's Hospital of Kunming - Department of Nephrology - Kunming - China.
  • Hussain SA; King Saud University - College of Science - Department of Zoology - Riyadh - Saudi Arabia.
  • Gangireddygari VSR; National Institute of Horticultural and Herbal Science - Plant Virus Research - Horticultural and Herbal Crop Environment Division - Rural Development Administration - Wanju - Republic of Korea.
  • Jiang X; The First People's Hospital of Kunming - Department of Nephrology - Kunming - China.
Acta Cir Bras ; 38: e385623, 2023.
Article em En | MEDLINE | ID: mdl-38055383
PURPOSE: Diabetes mellitus is a serious health problem worldwide, and diabetic nephropathy is the complication. The diabetic nephropathy considerably enhances the oxidative stress, glycation, lipid parameters and inflammatory reaction. Ellipticine has potent free radical scavenging and anti-inflammatory effect. METHODS: In the current study, our objectives were to thoroughly examine the renal protective effects of ellipticine in a rat model of streptozotocin (STZ)-induced diabetic nephropathy (DN) and to elucidate the underlying mechanisms involved. For the induction of diabetic nephropathy, streptozotocin (50 mg/kg) was used, and rats were separated into groups and given varying doses of ellipticine (2.5, 5 and 7.5 mg/kg). The body weight, and renal weight were estimated. The inflammatory cytokines, renal biomarkers, inflammatory antioxidant, and urine parameters were estimated. RESULTS: Result showed that ellipticine considerably enhanced the body weight and reduced the renal tissue weight. Ellipticine treatment significantly (P < 0.001) repressed the level of blood urea nitrogen, serum creatinine, uric acid, blood glucose and altered the lipid parameters. Ellipticine significantly (P < 0.001) repressed the level of malonaldehyde and boosted the glutathione, catalase, superoxide dismutase, and glutathione peroxidase. Ellipticine treatment significantly (P < 0.001) reduced the inflammatory cytokines and inflammatory mediators. CONCLUSIONS: Ellipticine could be a renal protective drug via attenuating the inflammatory reaction, fibrosis and oxidative stress in streptozotocin induced rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Nefropatias Diabéticas / Elipticinas Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2023 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus / Nefropatias Diabéticas / Elipticinas Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2023 Tipo de documento: Article País de publicação: Brasil