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Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae).
Silva, Mariza Severina de Lima; Silva, Marcilene Souza da; Cruz, Rômulo Carlos Dantas da; Veras, Bruno de Oliveira; Souza, Ivone Antonia de; Ximenes, Rafael Matos; de Aquino, Thiago Mendonça; Góes, Alexandre José da Silva.
Afiliação
  • Silva MSL; Departamento de Antibióticos, Universidade Federal de Pernambuco - UFPE, Av. Prof. Artur de Sá, s/n, 50.740-525, Recife, PE, Brazil.
  • Silva MSD; Departamento de Antibióticos, Universidade Federal de Pernambuco - UFPE, Av. Prof. Artur de Sá, s/n, 50.740-525, Recife, PE, Brazil.
  • Cruz RCDD; Departamento de Antibióticos, Universidade Federal de Pernambuco - UFPE, Av. Prof. Artur de Sá, s/n, 50.740-525, Recife, PE, Brazil.
  • Veras BO; Departamento de Bioquímica, Universidade Federal de Pernambuco - UFPE, Av. Prof. Moraes Rego, s/n, 50.670-420, Recife, PE, Brazil.
  • Souza IA; Departamento de Antibióticos, Universidade Federal de Pernambuco - UFPE, Av. Prof. Artur de Sá, s/n, 50.740-525, Recife, PE, Brazil.
  • Ximenes RM; Departamento de Antibióticos, Universidade Federal de Pernambuco - UFPE, Av. Prof. Artur de Sá, s/n, 50.740-525, Recife, PE, Brazil.
  • de Aquino TM; Instituto de Química e Biotecnologia, Universidade Federal de Alagoas - UFAL, Av. Lourival Melo Mota, s/n, 57.072-900, Maceió, AL, Brazil.
  • Góes AJDS; Departamento de Antibióticos, Universidade Federal de Pernambuco - UFPE, Av. Prof. Artur de Sá, s/n, 50.740-525, Recife, PE, Brazil. Electronic address: alexandre.goes@ufpe.br.
Exp Parasitol ; 256: 108657, 2024 Jan.
Article em En | MEDLINE | ID: mdl-38043764
Aedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benzodioxole group as a key pharmacophore associated with insecticidal activity. Therefore, this study aimed to synthesize and assess the larvicidal activity of 1,3-benzodioxole acids against Ae. aegypti, as well as their toxicity in mammals. Among the compounds evaluated, 3,4-(methylenedioxy) cinnamic acid (compound 4) demonstrated larvicidal activity. It exhibited LC50 and LC90 values of 28.9 ± 5.6 and 162.7 ± 26.2 µM, respectively, after 24 h of exposure. For reference, the positive control, temephos, displayed both LC50 and LC90 values below 10.94 µM. These findings underline the significance of the 3,4-methylenedioxy substituent on the aromatic ring and the presence of a double bond in the aliphatic chain for biological activity. Furthermore, compound 4 exhibited no cytotoxicity towards human peripheral blood mononuclear cells, even at concentrations up to 5200 µM. Lastly, in mice treated with 2000 mg kg-1, compound 4 showed mild behavioral effects and displayed no structural signs of toxicity in vital organs such as the kidney, liver, spleen, and lungs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aedes / Zika virus / Infecção por Zika virus / Inseticidas Limite: Animals / Humans Idioma: En Revista: Exp Parasitol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aedes / Zika virus / Infecção por Zika virus / Inseticidas Limite: Animals / Humans Idioma: En Revista: Exp Parasitol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos