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Postoperative Seizure Prophylaxis in Meningioma Resection: A Systematic Review and Meta-Analysis.
Batista, Sávio; Bertani, Raphael; Palavani, Lucca B; de Barros Oliveira, Leonardo; Borges, Pedro; Koester, Stefan W; Paiva, Wellingson Silva.
Afiliação
  • Batista S; Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.
  • Bertani R; Department of Neurosurgery, São Paulo University, Sao Paulo 05508-220, Brazil.
  • Palavani LB; Faculty of Medicine, Max Planck University Center, Indaiatuba 13343-060, Brazil.
  • de Barros Oliveira L; Faculty of Medicine, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.
  • Borges P; Faculty of Medicine, Fundação Técnico-Educacional Souza Marques, Rio de Janeiro 21310-310, Brazil.
  • Koester SW; School of Medicine, Vanderbilt University, Nashville, TN 37235, USA.
  • Paiva WS; Department of Neurosurgery, São Paulo University, Sao Paulo 05508-220, Brazil.
Diagnostics (Basel) ; 13(22)2023 Nov 09.
Article em En | MEDLINE | ID: mdl-37998550
BACKGROUND: Seizures in the early postoperative period may impair patient recovery and increase the risk of complications. The aim of this study is to determine whether there is any advantage in postoperative seizure prophylaxis following meningioma resection. METHODS: This systematic review was conducted in accordance with PRISMA guidelines. PUBMED, Web of Science, Embase, Science Direct, and Cochrane were searched for papers until April 2023. RESULTS: Among nine studies, a total of 3249 patients were evaluated, of which 984 patients received antiepileptic drugs (AEDs). No significant difference was observed in the frequency of seizure events between patients who were treated with antiepileptic drugs (AEDs) and those who were not. (RR 1.22, 95% CI 0.66 to 2.40; I2 = 57%). Postoperative seizures occurred in 5% (95% CI: 1% to 9%) within the early time period (<7 days), and 9% (95% CI: 1% to 17%) in the late time period (>7 days), with significant heterogeneity between the studies (I2 = 91% and 97%, respectively). In seizure-naive patients, the rate of postoperative seizures was 2% (95% CI: 0% to 6%) in the early period and increased to 6% (95% CI: 0% to 15%) in the late period. High heterogeneity led to the use of random-effects models in all analyses. CONCLUSIONS: The current evidence does not provide sufficient support for the effectiveness of prophylactic AED medications in preventing postoperative seizures in patients undergoing meningioma resection. This underscores the importance of considering diagnostic criteria and conducting individual patient analysis to guide clinical decision-making in this context.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Systematic_reviews Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Systematic_reviews Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça