Your browser doesn't support javascript.
loading
GXMR-CAR containing distinct GXM-specific single-chain variable fragment (scFv) mediated the cell activation against Cryptococcus spp. And had difference in the strength of tonic signaling.
Machado, Michele Procópio; Dos Santos, Matheus Henrique; Guimarães, Júlia Garcia; de Campos, Gabriela Yamazaki; Oliveira Brito, Patrícia Kellen Martins; Ferreira, Camilly Melo Garcia; Rezende, Caroline Patini; Frota, Natália Fernandes; Soares, Sandro Gomes; Kumaresan, Pappanaicken R; Lourenzoni, Marcos Roberto; da Silva, Thiago Aparecido.
Afiliação
  • Machado MP; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • Dos Santos MH; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • Guimarães JG; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • de Campos GY; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • Oliveira Brito PKM; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • Ferreira CMG; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • Rezende CP; Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
  • Frota NF; Federal University of Ceara (UFC), Fortaleza, Ceara, Brazil.
  • Soares SG; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Kumaresan PR; Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lourenzoni MR; Fundação Oswaldo Cruz Ceará (Fiocruz-CE), Research Group on Protein Engineering and Health Solutions (GEPeSS), Eusébio, Ceara, Brazil.
  • da Silva TA; Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao, Sao Paulo, Brazil.
Bioengineered ; 14(1): 2281059, 2023 12.
Article em En | MEDLINE | ID: mdl-37978838
2H1-GXMR-CAR and 18B7-GXMR-CAR are efficiently expressed on the cell surface;2H1-GXMR-CAR and 18B7-GXMR-CAR redirected T cells toward the ligands;18B7-GXMR-CAR provided highest levels of tonic signaling;Binding pocket of 18B7 scFv favored the tonic signaling triggered by GXMR-CAR;Binding pocket of 18B7 scFv favored the tonic signaling triggered by GXMR-CAR.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cryptococcus neoformans / Anticorpos de Cadeia Única / Receptores de Antígenos Quiméricos Limite: Humans Idioma: En Revista: Bioengineered Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cryptococcus neoformans / Anticorpos de Cadeia Única / Receptores de Antígenos Quiméricos Limite: Humans Idioma: En Revista: Bioengineered Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos