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Ru(II) based dual nitric oxide donors: electrochemical and photochemical reactivities and vasorelaxant effect with no cytotoxicity.
da Silva, Carlos D S; Ferreira, Kleber Q; Meira, Cássio S; Soares, Milena B P; Moraes, Raiana Dos Anjos; Araújo, Fênix Alexandra; Flavia Silva, Darizy; de Sá, Denise S.
Afiliação
  • da Silva CDS; Institute of Chemistry, Federal University of Bahia, Campus Ondina, 40170-290 Salvador, BA, Brazil. denisesa@ifba.edu.br.
  • Ferreira KQ; Department of Chemistry, Federal Institute of Bahia (IFBA), Salvador, 40301-15, Brazil.
  • Meira CS; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), 40296-710 Salvador, Bahia, Brazil.
  • Soares MBP; SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador, BA 41650-010, Brazil.
  • Moraes RDA; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), 40296-710 Salvador, Bahia, Brazil.
  • Araújo FA; Laboratory of Cardiovascular Physiology and Pharmacology, Institute of Health Sciences, Federal University of Bahia, Salvador, Av. Reitor Miguel Calmon, s/n - Canela, Salvador, BA, 40231-300, Brazil.
  • Flavia Silva D; Postgraduate Program in Biotechnology in Health and Investigative Medicine, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil.
  • de Sá DS; Laboratory of Cardiovascular Physiology and Pharmacology, Institute of Health Sciences, Federal University of Bahia, Salvador, Av. Reitor Miguel Calmon, s/n - Canela, Salvador, BA, 40231-300, Brazil.
Dalton Trans ; 52(46): 17176-17184, 2023 Nov 28.
Article em En | MEDLINE | ID: mdl-37937931
The synthesized complexes, cis-[Ru(NO)(NO2)(phen)2](PF6)2 (NONO2P) and cis-[Ru(NO)(NO2)(bpy)2](PF6)2 (NONO2B), were characterized by using elemental analysis, voltammetry and electronic and vibrational spectroscopy. Under electrochemical and photochemical stimulation in an aqueous medium, there are indications of the formation of complexes, which suggests that the nitro and nitrosyl groups are converted into nitric oxide. Both compounds do not show cytotoxic activity against human umbilical vein endothelial cells (HUVECs). The cis-[Ru(NO)(NO2)(phen)2](PF6)2 complex presented vasorelaxation activity in superior mesenteric arteries from Wistar rats: the biphasic concentration-response curve indicates two sites of action. In the presence of NO scavengers, we observed an impaired relaxing effect induced by NONO2P, suggesting that the vasorelaxant effect is due to NO production from this compound.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Doadores de Óxido Nítrico Limite: Animals / Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio / Doadores de Óxido Nítrico Limite: Animals / Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido