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Antifungal activity of citronellal against Trichophyton rubrum and its predictive mechanism of action by CYP51 inhibition through molecular docking.
Andrade Júnior, Francisco Patricio de; Galdino Gouveia, Rawny; Ilan Soares Medeiros, Cássio; Teixeira, Bráulio de Almeida; Farias, Brenda Kercya da Silva; Oliveira, Nayana da Rocha; Silva, Daniele de Figuerêdo; Lima, Edeltrudes de Oliveira.
Afiliação
  • Andrade Júnior FP; Master in Natural and Synthetic Bioactive Products, Federal University of Paraiba (UFPB), João Pessoa, Brazil.
  • Galdino Gouveia R; PhD in Natural and Synthetic Bioactive Products, UFPB, João Pessoa, Brazil.
  • Ilan Soares Medeiros C; PhD in Natural and Synthetic Bioactive Products, UFPB, João Pessoa, Brazil.
  • Teixeira BA; Master in Natural and Synthetic Bioactive Products, Federal University of Paraiba (UFPB), João Pessoa, Brazil.
  • Farias BKDS; Master in Natural and Synthetic Bioactive Products, Federal University of Paraiba (UFPB), João Pessoa, Brazil.
  • Oliveira NDR; Master in Natural and Synthetic Bioactive Products, Federal University of Paraiba (UFPB), João Pessoa, Brazil.
  • Silva DF; PhD in Natural and Synthetic Bioactive Products, UFPB, João Pessoa, Brazil.
  • Lima EO; Postgraduate Program in Natural and Synthetic Bioactive Products, UFPB, João Pessoa, Brazil.
Nat Prod Res ; : 1-9, 2023 Nov 07.
Article em En | MEDLINE | ID: mdl-37933528
The present study aimed to investigate the antifungal activity of citronellal (CIT) against clinical isolates of T. rubrum and to show the possible mechanism of action involved. The antifungal potential of CIT was evaluated from the Minimum Inhibitory Concentration (MIC), Minimum Fungicide Concentration (MFC) and assays with ergosterol and sorbitol, to elucidate the possible mechanisms of action, and molecular docking. MIC and MFC values ranged from 4 to 512 µg/mL. Regarding the mechanism of action, the monoterpene demonstrated interaction with fungal ergosterol. In addition, it is possible to observe that CIT acts on crucial enzymes for the biosynthesis and maintenance of the fungal cell membrane, due to the ability of the monoterpene to bind to CYP51. The results obtained in this research demonstrate that CIT has the potential to become, in the future, a product for the treatment of dermatophytosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido