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Bone quality, mineral density, and fractures in heart failure.
Canteri, Andre Luiz; Gusmon, Luana Bassan; Boguszewski, Cesar Luiz; Borba, Victoria Zeghbi Cochenski.
Afiliação
  • Canteri AL; Division of Cardiology, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná State, Brazil.
  • Gusmon LB; Health Sciences and Internal Medicine Postgraduation Department, Federal University of Paraná, Curitiba, Paraná State, Brazil.
  • Boguszewski CL; Division of Cardiology, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná State, Brazil.
  • Borba VZC; Health Sciences and Internal Medicine Postgraduation Department, Federal University of Paraná, Curitiba, Paraná State, Brazil.
PLoS One ; 18(11): e0293903, 2023.
Article em En | MEDLINE | ID: mdl-37922295
BACKGROUND: The trabecular bone score (TBS) indirectly estimates bone quality and predicts low-impact fractures independently of bone mineral density (BMD). However, there is still a paucity of data linking bone and heart diseases, mainly with gaps in the TBS analysis. METHODS: In this cross-sectional study, we evaluated TBS, BMD, and fractures in patients with heart failure with reduced ejection fraction (HFrEF) and in sex-, BMI- and age-matched controls, and we assessed the fracture probability using the FRAX tool, considering active search for fractures by vertebral fracture assessment (VFA) and the adjustment for the TBS. RESULTS: TBS values were 1.296 ± 0.14 in 85 patients (43.5% women; age 65 ± 13 years) and 1.320 ± 0.11 in 142 controls (P = 0.07), being reduced (< 1.31) in 51.8% and 46.1% of them, respectively (P = 0.12). TBS was lower in patients than in the controls when BMD was normal (P = 0.04) and when the BMI was 15-37 kg/m2 (P = 0.03). Age (odds ratio [OR] 1.05; P = 0.026), albumin (OR 0.12; P = 0.046), statin use (OR 0.27; P = 0.03), and energy intake (OR 1.03; P = 0.014) were associated with reduced TBS. Fractures on VFA occurred in 42.4% of the patients, and VFA and TBS adjustment increased the fracture risk by 16%-23%. CONCLUSION: Patients with HFrEF had poor bone quality, with a better discriminating impact of the TBS assessment when BMD was normal, and BMI was suitable for densitometric analysis. Variables related to the prognosis, severity, and treatment of HFrEF were associated with reduced TBS. VFA and TBS adjustment increased fracture risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fraturas da Coluna Vertebral / Fraturas por Osteoporose / Insuficiência Cardíaca Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fraturas da Coluna Vertebral / Fraturas por Osteoporose / Insuficiência Cardíaca Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos