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Copper(II) complexes of a furan-containing aroylhydrazonic ligand: syntheses, structural studies, solution chemistry and interaction with HSA.
Moura, Fagner da Silva; Sobrinho, Ygor S; Stellet, Carolina; Serna, Jilder D P; Ligiero, Carolina B P; Yoguim, Maurício I; Cukierman, Daphne S; Diniz, Renata; Alves, Odivaldo C; Morgon, Nelson H; de Souza, Aguinaldo R; Rey, Nicolás A.
Afiliação
  • Moura FDS; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. nicoarey@puc-rio.br.
  • Sobrinho YS; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. nicoarey@puc-rio.br.
  • Stellet C; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. nicoarey@puc-rio.br.
  • Serna JDP; Brazilian Center for Physical Research, Rio de Janeiro, Brazil.
  • Ligiero CBP; Chemistry Institute, Fluminense Federal University, Niterói, Brazil.
  • Yoguim MI; Department of Chemistry, Paulista State University Júlio de Mesquita Filho, Bauru, Brazil.
  • Cukierman DS; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. nicoarey@puc-rio.br.
  • Diniz R; Chemistry Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Alves OC; Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Morgon NH; Chemistry Institute, Fluminense Federal University, Niterói, Brazil.
  • de Souza AR; Chemistry Institute, Campinas State University, Campinas, Brazil.
  • Rey NA; Department of Chemistry, Paulista State University Júlio de Mesquita Filho, Bauru, Brazil.
Dalton Trans ; 52(47): 17731-17746, 2023 Dec 05.
Article em En | MEDLINE | ID: mdl-37916692
Copper(II) complexes have become a potential alternative to the use of platinum drugs in cancer therapy due to their multi-target mode of action. In this context, we report the syntheses of new mononuclear and dinuclear coordination compounds of this element, 1 and 2, derived from the ligand 5-methylsalicylaldehyde 2-furoyl hydrazone (H2L). All three compounds were structurally and spectroscopically characterized, both in the solid state and in solution. In 1, Cu is coordinated by three donor-atoms from the hydrazonic ligand and one chloride ion. H2L is deprotonated at the phenol oxygen. The dinuclear complex 2 is, on the other hand, a dimeric form of 1 in which the chloride ions of a pair of mononuclear units are lost and phenoxo bridges take their places, double-connecting the metal centres and resulting in a single species with the ligand fully deprotonated. The compounds were fairly stable in aqueous medium at room temperature. An experimental-theoretical combined approach demonstrated that all of them are able to bind human serum albumin (HSA), although at different sites and with diverse stoichiometries and affinities (as concluded by the calculated binding energies). In view of this, and due to the well-known antiproliferative activity of hydrazone-containing copper complexes, we consider the compounds presented in here promising, and believe that they deserve more profound studies regarding the assessment of their potential against tumour cell lines.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Albumina Sérica Humana Limite: Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Albumina Sérica Humana Limite: Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido