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A Review of Cartilage Defect Treatments Using Chitosan Hydrogels in Experimental Animal Models.
Silva, Lais Caroline Souza E; Martignago, Cintia Cristina Santi; Motta, Homero Garcia; Silva, Mirian Bonifacio; Avanzi, Ingrid Regina; Assis, Lívia; Ribeiro, Daniel Araki; Parisi, Julia Risso; Rennó, Ana Claudia.
Afiliação
  • Silva LCSE; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Martignago CCS; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Motta HG; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Silva MB; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Avanzi IR; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Assis L; Scientific and Technological Institute, Brazil University, São Paulo, 08230-030, Brazil.
  • Ribeiro DA; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Parisi JR; Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Santos, SP, 11015020, Brazil.
  • Rennó AC; Metropolitan University of Santos (UNIMES), General Francisco Glicério Avenue, 8, Santos, SP, 11045-002, Brazil.
Curr Pharm Biotechnol ; 2023 Oct 24.
Article em En | MEDLINE | ID: mdl-37916637
INTRODUCTION: Chitosan (CS) is a polycationic polysaccharide comprising glucosamine and N-acetylglucosamine and constitutes a potential material for use in cartilage tissue engineering. Moreover, CS hydrogels are able to promote the expression of cartilage matrix components and reduce inflammatory and catabolic mediator production by chondrocytes. Although all the positive outcomes, no review has analyzed the effects of CS hydrogels on cartilage repair in animal models. METHODS: This study aimed to review the literature to examine the effects of CS hydrogels on cartilage repair in experimental animal models. The search was done by the descriptors of the Medical Subject Headings (MeSH) defined below: "Chitosan," "hydrogel," "cartilage repair," and "in vivo." A total of 420 articles were retrieved from the databases Pubmed, Scopus, Embase, Lilacs, and Web of Science. After the eligibility analyses, this review reported 9 different papers from the beginning of 2002 through the middle of 2022. RESULTS: It was found that cartilage repair was improved with the treatment of CS hydrogel, especially the one enriched with cells. In addition, CS hydrogel produced an upregulation of genes and proteins that act in the cartilage repair process, improving the biomechanical properties of gait. CONCLUSION: In conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate the process of cartilage repair in animal studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Curr Pharm Biotechnol Assunto da revista: BIOTECNOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Curr Pharm Biotechnol Assunto da revista: BIOTECNOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda