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Chitosan-PEG Gels Loaded with Jatropha mollissima (Pohl) Baill. Ethanolic Extract: An Efficient and Effective Biomaterial in Hemorrhage Control.
Rodrigues, José F B; Queiroz, João V S de A; Medeiros, Rebeca P; Santos, Rafaela O; Fialho, Djair A; Neto, João E S; Santos, Rogério L Dos; Barbosa, Rossemberg C; Sousa, Wladymyr J B; Torres, Maria da C de M; Medeiros, Luanna A D M; Silva, Suédina M de L; Montazerian, Maziar; Fook, Marcus V L; Amoah, Solomon K S.
Afiliação
  • Rodrigues JFB; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Queiroz JVSA; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Medeiros RP; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Santos RO; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Fialho DA; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Neto JES; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Santos RLD; Department of Dentistry, Life Science Institute, Federal University of Juiz de Fora, Governador Valadares 36036-900, MG, Brazil.
  • Barbosa RC; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Sousa WJB; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Torres MDCM; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Medeiros LADM; Chemistry Department, Science and Technology Center, State University of Paraiba, Campina Grande 58429-500, PB, Brazil.
  • Silva SML; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Montazerian M; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Fook MVL; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
  • Amoah SKS; Materials Science and Engineering Department, Northeast Laboratory for Evaluation and Development of Biomaterials, Academic Unit of Materials Science and Engineering, Federal University of Campina Grande, Campina Grande 58429-000, PB, Brazil.
Pharmaceuticals (Basel) ; 16(10)2023 Oct 03.
Article em En | MEDLINE | ID: mdl-37895870
A lack of control over blood loss can have catastrophic implications, including death. Although several hemostatic medications have been employed to reduce bleeding, a vast majority of them are ineffective, expensive, or pose health risks to the patient. To overcome these constraints, chitosan-polyethylene glycol (CS-PEG) hemostatic gels loaded with ethanolic extract of Jatropha mollissima sap (EES) were prepared and their hemostatic, physicochemical, and cytotoxic properties were evaluated. The gels were produced by mixing CS with PEG (an external plasticizer) and EES. The phytochemical analysis revealed a significant concentration of total polyphenols and tannins content in the extract and catechin was identified as one of the key compounds of EES. Infrared spectroscopy analysis revealed the presence of EES in the gels, as well as the chemical interaction between CS and PEG. The gels were thermally stable between 25 and 37 °C (ambient and human body temperature range), had pseudoplastic deformation behavior (rheological properties preserved after shearing), were simple to inject (compression force 30 N), and were biocompatible. In vivo experiments showed that both CS-PEG-EES gels exhibited greater hemostatic action in preventing tail hemorrhage in Wistar rats, with decreased bleeding time and blood weight compared with unloaded CS-PEG gels (control groups) and Hemostank, a commercial product. However, the gel prepared with acetic acid was more efficient in controlling bleeding. These findings reveal that CS-PEG-EES gels can reduce hemorrhages and are a potent, simple, and safe hemostatic agent.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça