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Antibacterial and immunological properties of piperine evidenced by preclinical studies: a systematic review.
Murase, Letícia Sayuri; Perez de Souza, João Vítor; Meneguello, Jean Eduardo; Palomo, Carolina Trevisolli; Fernandes Herculano Ramos Milaré, Áquila Carolina; Negri, Melyssa; Dias Siqueira, Vera Lúcia; Demarchi, Izabel Galhardo; Vieira Teixeira, Jorge Juarez; Cardoso, Rosilene Fressatti.
Afiliação
  • Murase LS; Postgraduate Program in Health Sciences, State University of Maringa, Maringá, Paraná, 87020-900, Brazil.
  • Perez de Souza JV; Postgraduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
  • Meneguello JE; Postgraduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
  • Palomo CT; Postgraduate Program in Health Sciences, State University of Maringa, Maringá, Paraná, 87020-900, Brazil.
  • Fernandes Herculano Ramos Milaré ÁC; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
  • Negri M; Postgraduate Program in Health Sciences, State University of Maringa, Maringá, Paraná, 87020-900, Brazil.
  • Dias Siqueira VL; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
  • Demarchi IG; Postgraduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
  • Vieira Teixeira JJ; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
  • Cardoso RF; Department of Clinical Analysis, Federal University of Santa Catarina, Florianopólis, Santa Catarina, 88040-900, Brazil.
Future Microbiol ; 18: 1279-1299, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37882762
Aim: To review in vitro, in vivo, and in silico studies examining the antibacterial and immunomodulatory properties of piperine (PPN). Methods: This systematic review followed PRISMA guidelines, and five databases were searched. Results: A total of 40 articles were included in this study. Six aspects of PPN activity were identified, including antibacterial spectrum, association with antibiotics, efflux pump inhibition, biofilm effects, protein target binding, and modulation of immune functions/virulence factors. Most studies focused on Mycobacterium spp. and Staphylococcus aureus. Cell lineages and in vivo models were employed to study PPN antibacterial effects. Conclusion: We highlight PPN as a potential adjuvant in the treatment of bacterial infections. PPN possesses several antibacterial properties that need further exploration to determine the mechanisms behind its pharmacological activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides / Antibacterianos Tipo de estudo: Systematic_reviews Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides / Antibacterianos Tipo de estudo: Systematic_reviews Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido