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Assessment of the in Vitro Antimelanoma Potential of Lippia microphylla Cham (Verbenaceae) Essential Oil.
de Oliveira Lopes, Ana Luiza; Neves de Andrade, Camyla Caroliny; Sousa Duarte, Sâmia; Gadelha Marques, Karinne Kelly; Ramos Marques de Souza, Ramon; de Lourdes Assunção Araújo de Azevedo, Fátima; Fechine Tavares, Josean; Dos Santos Golzio, Sócrates; Ramos Gonçalves, Juan Carlos; Sobral, Marianna Vieira.
Afiliação
  • de Oliveira Lopes AL; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Neves de Andrade CC; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Sousa Duarte S; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Gadelha Marques KK; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Ramos Marques de Souza R; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • de Lourdes Assunção Araújo de Azevedo F; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Fechine Tavares J; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Dos Santos Golzio S; Department of Pharmaceutical Sciences, Federal University of Paraíba, CEP, 58051-900, João Pessoa, PB, Brazil.
  • Ramos Gonçalves JC; Post Graduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, CEP 58051-900, João Pessoa, PB, Brazil.
  • Sobral MV; Department of Pharmaceutical Sciences, Federal University of Paraíba, CEP, 58051-900, João Pessoa, PB, Brazil.
Chem Biodivers ; 20(11): e202300717, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37867470
Essential oils stand out among natural products for their complex composition, frequently described in the literature with a range of biological effects. This study evaluated the cytotoxic activity against several human cancer cell lines of essential oils extracted from the leaves of Lippia microphylla (EO-LM) Cham. (Verbenaceae). The melanoma cell line SK-MEL-28 was the most sensitive to the EO-LM, presenting an IC50 of 33.38±1.16 µg/mL. Afterward, the effects of EO-LM on the cell cycle, induction of apoptosis, and production of reactive oxygen species (ROS) were evaluated. We stated a significant increase in the sub-G1 population, indicating apoptosis, later confirmed by an increase of SK-MEL-28 cells labeled with Annexin V-FITC and by the formation of apoptotic bodies and membrane blebs, observed by confocal microscopy. Additionally, EO-LM reduced the production of ROS, indicating antioxidant activity. Therefore, EO-LM exhibits anti-melanoma activity in vitro, suggesting its potential as an anticancer agent.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Verbenaceae / Lippia Limite: Humans Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Verbenaceae / Lippia Limite: Humans Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça