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Epidemiological profile and genetic resistance of Neisseria gonorrhoeae infection in women in a poor region of São Paulo, Brazil.
Tavares, Gabriela Martinez Moura; Alverga, Hannar Angélica de Melo; Felix, Estela Moraes; Dichman, Giovana de Oliveira; Pinheiro, Gabriel Monteiro; Juliano, Yara; Paruci, Priscila; Fujita, Dennis Minoru; Neves, Lucas Melo; Shio, Marina Tiemi; Nali, Luiz Henrique da Silva.
Afiliação
  • Tavares GMM; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Alverga HAM; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Felix EM; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Dichman GO; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Pinheiro GM; Hospital Escola Wladimir Arruda - Santo Amaro University Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Juliano Y; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Paruci P; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Fujita DM; Laboratório de protozoologia - IMT-USP/LIM49 - HCFMUSP -, Av. Dr. Enéas de Carvalho Aguiar, 470 São Paulo, Brazil. Electronic address: dmfujita@terra.com.br.
  • Neves LM; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Shio MT; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
  • Nali LHDS; Post-graduation Program in Health Sciences, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340, São Paulo 04829-300, Brazil.
Acta Trop ; 249: 107047, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37866730
ABSTRACT
BACKGROUND AND

AIM:

Gonorrhea is a bacterial infection in the urogenital tract, transmitted by sexual or perinatal contact, caused by Neisseria gonorrhoeae, a gram-negative diplococcus. The present study evaluates the frequency of N. gonorrhoeae in women treated at Hospital Wladimir Arruda in poor area of São Paulo and also verifies the presence of genetic resistance against three antimicrobials of different classes Tetracycline, Azithromycin and Ciprofloxacin.

METHODS:

This is an observational and descriptive study with a quantitative approach. Samples were collected at Hospital Escola Wladimir Arruda. The volunteers are women from 16 to 65 years of age. Sociodemographic, gynecological, sexual and health data are collected through a questionnaire, their symptoms/clinical manifestation were requested by the medical records, and then the participant is referred for collection of samples of cervical vaginal smear. The samples were screened for N. gonorrhoeae (dcmH gene) and tested for resistance genes to Tetracycline, Azithromycin and Ciprofloxacin through PCR.

RESULTS:

In the total of 127 samples analyzed by Real-Time PCR, 23 were positive and correspond to a general prevalence of a gonococcal infection in the studied population of 17% (CI95%), and the participants were married (43.4%), had active sexual life (56.5%) and did not use any type of condom during sexual intercourse (52.1%). The resistance to the tetM ribosomal gene was found in 14 samples, prevalence of 60% (CI= 95%).

CONCLUSIONS:

We have described a concerning frequency of N. gonorrhoeae infection in females attended in an outcare patient. Also, most of the strains detected presented resistance to one or more antimicrobials.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gonorreia / Anti-Infecciosos Limite: Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Trop Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gonorreia / Anti-Infecciosos Limite: Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Acta Trop Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda