Your browser doesn't support javascript.
loading
LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY.
Wiederkehr, Henrique de Aguiar; Wiederkehr, Julio Cesar; Da Igreja, Mauro Rafael; Ramos, Eduardo Brommelstroet; Nogara, Marcelo Scheidemantel; Soffiatti, Debora Stroparo; Massutti, Andrew; Sasaki, Vivian Laís; Wiederkehr, Barbara de Aguiar; Valejo, Igor Raphael Mathias; Coelho, Júlio Cezar Uili.
Afiliação
  • Wiederkehr HA; Universidade Federal do Paraná, University Hospital, Liver Transplant Department, Curitiba (PR), Brazil.
  • Wiederkehr JC; Universidade Federal do Paraná, University Hospital, Liver Transplant Department, Curitiba (PR), Brazil.
  • Da Igreja MR; Santa Isabel Hospital, Liver Transplant Department, Blumenau (SC), Brasil.
  • Ramos EB; Santa Isabel Hospital, Liver Transplant Department, Blumenau (SC), Brasil.
  • Nogara MS; Nossa Senhora das Graças Hospital, Liver Transplant Department, Curitiba (PR), Brazil.
  • Soffiatti DS; Santa Isabel Hospital, Liver Transplant Department, Blumenau (SC), Brasil.
  • Massutti A; Santa Isabel Hospital, Liver Transplant Department, Blumenau (SC), Brasil.
  • Sasaki VL; Santa Isabel Hospital, Liver Transplant Department, Blumenau (SC), Brasil.
  • Wiederkehr BA; Nossa Senhora das Graças Hospital, Liver Transplant Department, Curitiba (PR), Brazil.
  • Valejo IRM; Santa Isabel Hospital, Liver Transplant Department, Blumenau (SC), Brasil.
  • Coelho JCU; Universidade Federal do Paraná, University Hospital, Liver Transplant Department, Curitiba (PR), Brazil.
Arq Bras Cir Dig ; 36: e1769, 2023.
Article em En | MEDLINE | ID: mdl-37851755
BACKGROUND: The prevalence of primary sclerosing cholangitis (PSC) in the general population has not yet been clearly established. The management of PSC should focus on delaying the progression of the disease and restraining its complications. The only curative therapy for the disease remains liver transplantation (LT). PSC is currently the fifth most common indication for LT and corresponds to 5% of all LT indications in adults. AIMS: Our objective is to evaluate the indications and outcomes of PSC patients undergoing LT in three liver transplantation centers in southern Brazil - Hospital Santa Isabel in Blumenau, Santa Catarina state, and Hospital das Clínicas and Hospital Nossa Senhora das Graças, in Curitiba, Parana state). METHODS: This is a longitudinal observational study of patients with PSC who underwent LT in three major Brazilian medical centers. Electronic medical records and study protocols of all patients subjected to LT from January 2011 to December 2021 were retrospectively reviewed. RESULTS: Of the 1,362 transplants performed in the three medical centers, 37 were due to PSC. Recurrence of PSC occurred in three patients (8.1%) in 3.0±2.4 years (range, 1-4 years). The 1-year and 5-year survival rates after the first LT were 83.8 and 80.6%, respectively. The 1-year and 5-year graft survival rates were, respectively, 83.8 and 74.8%. CONCLUSIONS: Our experience with LT in patients with PSC demonstrated good patient and graft survival results. Most deaths were due to common factors in patients undergoing LT.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colangite Esclerosante / Transplante de Fígado Limite: Adult / Humans Idioma: En Revista: Arq Bras Cir Dig Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colangite Esclerosante / Transplante de Fígado Limite: Adult / Humans Idioma: En Revista: Arq Bras Cir Dig Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil