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Efficacy of methenamine with methylthioninium in the treatment of dysuria: a randomized clinical study.
Neto, Felício Savioli; Hachul, Helena; Pereira, Márcio Antônio; Filho, Carlos Isaia.
Afiliação
  • Neto FS; Dr. Felício Savioli Neto Cardiologia e Cardiogeriatria, Cotia, SP, Brazil.
  • Hachul H; Department of Psicobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Pereira MA; ISPEM - Instituto São José dos Campos em Pesquisas Médicas, São José dos Campos, SP, Brazil.
  • Filho CI; Centro de Medicina Reprodutiva Dr. Carlos Isaia Filho, Rua Hilário Ribeiro 202/304, Porto Alegre, RS, Brazil. isaia@isaia.com.br.
Int Urogynecol J ; 34(12): 3051-3058, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37851092
INTRODUCTION AND HYPOTHESIS: Dysuria is a common symptom present in several urological and gynecological conditions. Management relies on the underlying disease but may require additional symptomatic treatment. This study evaluated the combination of methenamine 250 mg and methylthioninium chloride 20 mg in the treatment of dysuria versus phenazopyridine. METHODS: This was a multicenter, single-blind, randomized, superiority clinical trial, including individuals over 18 with dysuria and a score ≥ 5 points on the pre-treatment categorical scale for pain. The primary outcome was the proportion of participants presenting excellent clinical response within 24 h after treatment. Improvement up to 72 h, time to reach improvement, sustained healing, investigators' opinion, and safety were also evaluated. RESULTS: Three hundred and fifteen participants were evaluated. Demographic characteristics and symptoms of dysuria were comparable between groups at baseline. The difference in the excellent response rate between treatments within 24 h was 12.7% (95% CI 6.16, 19.21) for pain, 9.4% (95% CI 3.32, 15.39) for burning, and 12.7% (95% CI 6.37, 18.99) for burning on urination, all in favor of the test drug, which was also superior from 36 to 48 h. Treatments were similar concerning time to reach the absence of symptoms and in the percentage of participants with sustained healing after 72 h. CONCLUSIONS: The association of methenamine with methylthioninium is superior to phenazopyridine in the treatment of dysuria.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disuria / Metenamina Limite: Adult / Humans Idioma: En Revista: Int Urogynecol J Assunto da revista: GINECOLOGIA / UROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disuria / Metenamina Limite: Adult / Humans Idioma: En Revista: Int Urogynecol J Assunto da revista: GINECOLOGIA / UROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido