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Avocado Paste Phenolics Mitigate a High-Fat Diet-Induced Plasma HDL Decrease in Male Wistar Rats, by Altering the mRNA Expression of Hepatic SCARB1.
Domínguez-Avila, J Abraham; Salazar-López, Norma J; Montiel-Herrera, Marcelino; Corella-Salazar, Diana A; Rodrigo-Garcia, Joaquín; Astiazaran-Garcia, Humberto; Villegas-Ochoa, Mónica A; González-Aguilar, Gustavo A.
Afiliação
  • Domínguez-Avila JA; CONAHCYT-Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304, Hermosillo, Sonora, Mexico. abrahamdominguez9@gmail.com.
  • Salazar-López NJ; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304, Hermosillo, Sonora, Mexico.
  • Montiel-Herrera M; Facultad de Medicina de Mexicali, Universidad Autónoma de Baja California, Dr. Humberto Torres Sanginés S/N, Centro Cívico, 21000, Mexicali, Baja California, Mexico.
  • Corella-Salazar DA; Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Avenida Luis Donaldo Colosio y Calle de la Reforma, Centro, 83000, Hermosillo, Sonora, Mexico.
  • Rodrigo-Garcia J; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304, Hermosillo, Sonora, Mexico.
  • Astiazaran-Garcia H; Departamento de Ciencias de la Salud. Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del Pronaf y Estocolmo s/n, 32310, Ciudad Juárez, Chihuahua, Mexico.
  • Villegas-Ochoa MA; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304, Hermosillo, Sonora, Mexico.
  • González-Aguilar GA; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304, Hermosillo, Sonora, Mexico.
Cell Biochem Biophys ; 82(1): 119-126, 2024 Mar.
Article em En | MEDLINE | ID: mdl-37831306
Avocado paste (AP) is the main industrial byproduct of its processing, and retains various phenolic compounds (PCs). PCs are known to normalize the plasma lipid profile, but those from avocado byproducts have been minimally studied. We report the normalizing effects of an AP-derived phenolic extract (PE) on the plasma lipid profile of male Wistar rats. A standard (SD) and high-fat diet (HFD) were formulated, and the same diets were supplemented with 1 g/kg of diet of PE (SD + PE and HFD + PE). Rats were fed these diets during an 8-week period. The HFD induced signs of dyslipidemia, but PE treatment countered the decrease in HDL. Relative mRNA expression (real-time PCR) of the hepatic HDL receptor (SCARB1) increased in both groups (SD + PE and HFD + PE), while the LDR receptor (LDLR) increased in SD + PE group. The mRNA expression of apolipoproteins APOA1 and APOB was unaffected. We conclude that PCs from AP can counter a diet-induced decrease in plasma HDL by acting on the mRNA expression of its hepatic receptor.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Persea / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Cell Biochem Biophys Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Persea / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Cell Biochem Biophys Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos