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The effects of heat stress on intrauterine development, reproductive function, and ovarian gene expression of F1 female mice as well as gene expression of F2 embryos†.
Silva, José R; Souza-Fabjan, Joanna M G; Bento, Tays F M; Silva, Robson Campos; Moura, Cristiane R F; Bartlewski, Pawel M; Batista, Ribrio I T P.
Afiliação
  • Silva JR; Programa de Pós-Graduação em Ciência e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • Souza-Fabjan JMG; Programa de Pós-Graduação em Ciência e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • Bento TFM; Faculdade de Veterinária, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • Silva RC; Programa de Pós-Graduação em Ciência e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • Moura CRF; Departamento de Ciências Básicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil.
  • Bartlewski PM; Departamento de Ciências Básicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil.
  • Batista RITP; Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Biol Reprod ; 110(1): 33-47, 2024 Jan 13.
Article em En | MEDLINE | ID: mdl-37812452
Exposure to heat stress (HS) in utero was postulated to trigger an adaptive molecular response that can be transmitted to the next generation. Hence, this study assessed the impact of HS exposure at different stages of the gestational period of mice on the female F1 population and their offspring. Heat stress exposure (41°C and 65% relative humidity-RH) occurred during the first half (FP), the second half (SP), or the entire pregnancy (TP). A control group (C) was maintained in normothermic conditions (25°C, 45% RH) throughout the experiment. Heat stress had a significant negative effect on intrauterine development, mainly when HS exposure occurred in the first half of pregnancy (FP and TP groups). Postnatal growth of FP and TP mice was hindered until 4 weeks of age. The total number of follicles per ovary did not vary (P > 0.05) between the control and HS-exposed groups. Mean numbers of primordial follicles were lower (P < 0.05) in the sexually mature FP than those in SP and TP F1 females. However, the mean number of viable embryos after superovulation was lower (P < 0.05) in TP compared with C group. The expression of genes associated with physiological and cellular response to HS, autophagy, and apoptosis was significantly affected in the ovarian tissue of F1 females and F2 in vivo-derived blastocysts in all HS-exposed groups. In conclusion, exposure to HS during pregnancy compromised somatic development and reproductive parameters as well as altered gene expression profile that was then transmitted to the next generation of mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ovário / Efeitos Tardios da Exposição Pré-Natal Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Biol Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ovário / Efeitos Tardios da Exposição Pré-Natal Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Biol Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos