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Doxycycline for Multidrug-Resistant Gram-Negative Bacterial Infection Treatment: A Scoping Review.
de Macedo, Viviane; Meneghete, Bruno Pandolfo; Koaski, José Cassiano; Albuquerque, Ariádne Sousa; Fachi, Mariana Millan.
Afiliação
  • de Macedo V; Department of Infectious Diseases, Hospital Infection Control and Epidemiology Center, Santa Casa de Curitiba, Curitiba, Paraná, Brazil.
  • Meneghete BP; Department of Infectious Diseases, Medicine School, Positive University, Curitiba, Paraná, Brazil.
  • Koaski JC; Department of Infectious Diseases, Medicine School, Positive University, Curitiba, Paraná, Brazil.
  • Albuquerque AS; Department of Infectious Diseases, Hospital Infection Control and Epidemiology Center, Santa Casa de Curitiba, Curitiba, Paraná, Brazil.
  • Fachi MM; Value Management Office, Hospital Pequeno Príncipe, Curitiba, Paraná, Brazil.
J Glob Infect Dis ; 15(3): 95-100, 2023.
Article em En | MEDLINE | ID: mdl-37800083
Introduction: Multidrug-resistant bacterial infections limit available therapeutic options. Doxycycline is an old antibiotic from the tetracycline class that exhibits a wide antibacterial action, including Gram-negative bacteria (GNB), and could be an alternative for the treatment of multidrug-resistant (MDR) Enterobacteriaceae. The study aimed to systematically identify, evaluate, and summarize the results of studies related to outcomes of treatments for MDR-GNB infections in patients treated with doxycycline. Methods: This review was conducted in four databases during weeks 41-52 of 2022: PubMed, Medline, Scopus, and Web of Science, from the earliest year available on each database to December 2022. Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines were followed in conducting this study, and PICO was used for the research question of this review. Results: This scoping review found 8 retrospective studies that included 59 patients. Of these, 69% were treated for ventilator-associated pneumonia (VAP), 27% for urinary tract infections, 2% for bloodstream infections, and 2% for wound infections, both of which were associated with VAP. The usual dosage of doxycycline was 100 mg intravenously or orally. Clinical and microbiologic improvements were achieved in 81.3% and 87% of all patients, respectively. The mortality rate was 17.3% and was exclusively due to VAP. Conclusions: Doxycycline showed promising results in this review; however, randomized clinical trials or prospective cohorts are recommended to demonstrate the efficacy of doxycycline in the treatment of MDR infections with GNB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: J Glob Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Índia
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline / Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: J Glob Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Índia