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Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid.
Balas, Antonio; Moreno-Hidalgo, Miguel Ángel; de la Calle-Prieto, Fernando; Vicario, José Luis; Arsuaga, Marta; Trigo, Elena; de Miguel-Buckley, Rosa; Bellón, Teresa; Díaz-Menéndez, Marta.
Afiliação
  • Balas A; Histocompatibility Unit, Centro de Transfusion de la Comunidad de Madrid, Madrid, Spain.
  • Moreno-Hidalgo MÁ; Histocompatibility Unit, Centro de Transfusion de la Comunidad de Madrid, Madrid, Spain.
  • de la Calle-Prieto F; National Referral Unit for Imported Tropical Diseases and Travel Medicine, Infectious Diseases Department, Hospital Universitario La Paz-Carlos III, IdiPAZ, CIBERINFEC, Madrid, Spain.
  • Vicario JL; Histocompatibility Unit, Centro de Transfusion de la Comunidad de Madrid, Madrid, Spain.
  • Arsuaga M; National Referral Unit for Imported Tropical Diseases and Travel Medicine, Infectious Diseases Department, Hospital Universitario La Paz-Carlos III, IdiPAZ, CIBERINFEC, Madrid, Spain.
  • Trigo E; National Referral Unit for Imported Tropical Diseases and Travel Medicine, Infectious Diseases Department, Hospital Universitario La Paz-Carlos III, IdiPAZ, CIBERINFEC, Madrid, Spain.
  • de Miguel-Buckley R; National Referral Unit for Imported Tropical Diseases and Travel Medicine, Infectious Diseases Department, Hospital Universitario La Paz-Carlos III, IdiPAZ, CIBERINFEC, Madrid, Spain.
  • Bellón T; Institute for Health Research Hospital Universitario La Paz (IdiPAZ), Madrid, Spain. Electronic address: teresa.bellon@salud.madrid.org.
  • Díaz-Menéndez M; National Referral Unit for Imported Tropical Diseases and Travel Medicine, Infectious Diseases Department, Hospital Universitario La Paz-Carlos III, IdiPAZ, CIBERINFEC, Madrid, Spain.
Hum Immunol ; 84(11): 571-577, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37777360
BACKGROUND: Immigrants represented 21.8% of cases in a Spanish cohort of hospitalised patients with COVID-19, a proportion exceeding the percentage of immigrants in that area's total population. Among the ethnic-related genetic risk factors for COVID-19, human leukocyte antigen (HLA) genotypes in diverse populations might bias the response to SARS-CoV-2 infection and/or progression. Similarly, genetic differences in natural killer-activating and inhibitory receptors could play a role in the immune system's response to the viral infection. METHODS: We characterised HLA alleles and KIR genes in 52 Ecuadorian patients hospitalised for moderate and severe COVID-19 and 87 Ecuadorian controls from the general population living in the same area. RESULTS: There was a significantly increased frequency of the HLA-B*39 antigen and the activating KIR2DS4 receptor in the presence of its HLA-C*04 ligand in the COVID-19 group when compared with the control group. In contrast, there was a significant reduction in the frequency of carriers of KIR2DL1 and of the KIR3DL1/Bw4 receptor/ligand combination among COVID-19 group. On the other hand, HLA-A*24:02 and HLA-DRB1*09:01 alleles showed significantly lower frequencies specifically in the severe COVID-19 group. CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores KIR / COVID-19 Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Hum Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores KIR / COVID-19 Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Hum Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Espanha País de publicação: Estados Unidos