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Isolated Nocturnal Hypertension in People Living With Human Immunodeficiency Virus: A Cross-Sectional Study.
Zanuzzi, Matias G; López, Silvina M; Cattaneo, Máximo J; Pérez-Maure, María A; Lahiri, Cecile D; Romero, Cesar A.
Afiliação
  • Zanuzzi MG; Servicio de Clínica Médica, Hospital Privado de Córdoba, Córdoba, Argentina.
  • López SM; Servicio de Clínica Médica, Hospital Rawson de Córdoba, Córdoba, Argentina.
  • Cattaneo MJ; Servicio de Clínica Médica, Hospital Rawson de Córdoba, Córdoba, Argentina.
  • Pérez-Maure MA; Servicio de Clínica Médica, Hospital Rawson de Córdoba, Córdoba, Argentina.
  • Lahiri CD; Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.
  • Romero CA; Renal Division, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Am J Hypertens ; 37(2): 127-133, 2024 Jan 16.
Article em En | MEDLINE | ID: mdl-37777195
BACKGROUND: Nocturnal hypertension (NH) is a potent cardiovascular risk factor described frequently in people with HIV (PWH). Isolated NH (INH) is less well reported in PWH because of the need for ambulatory blood pressure monitoring (ABPM) in office normotensive patients. We aim to document the prevalence of NH and INH and the clinical factors associated with these phenotypes. METHODS: Cross-sectional study from an HIV program in Argentina. Office and ABPM measurements, as well as clinical and laboratory exploration, were performed. We defined INH as NH with daytime normotension in patients with office normotension. RESULTS: We obtained ABPM in 66 PWH, 60% male, aged 44.7 (IQR 27-69) years; 87% receiving antiretroviral therapy, and 86.2% virologically suppressed. ABPM-based hypertension prevalence was 54.7% (95% CI: 42.5-66.3). The prevalence of NH was 48.5% (32/66), while the INH prevalence was 19.7% (95% CI: 11.7-30.9). No differences were found regarding sex, HIV viral load, CD4+ T lymphocytes count, or years of infection between normotensive and INH patients. Multiple linear regression model adjusted for sex and age determined that body mass index (ß = 0.93, P < 0.01), plasma uric acid (ß = 0.25, P = 0.04), plasma potassium (ß = -10.1, P = 0.01), and high-sensitivity C-reactive protein (hs-CRP) (ß = 0.78, P = 0.02) independently predicted nocturnal systolic blood pressure (BP) in PWH. In a multiple logistic regression model adjusted for age and sex, the presence of sedentariness, plasma potassium <4 mEq/L, BMI, and hs-CRP levels were predictors of INH. CONCLUSION: INH is highly prevalent in PWH. Metabolic and inflammatory markers predict nocturnal SBP in PWH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Hipertensão Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Hipertensão Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos