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In vitro chemopreventive and cytotoxic effects of Amazon mosses Leucobryum martianum (Hornsch.) and Leucobryum laevifolium (Broth) extracts.
Fernandes, Andreia da Silva; de Oliveira, Carine Gonçalves; Evangelista, Heitor; Sulamita D S, Maria; Araujo-Lima, Carlos Fernando; Felzenszwalb, Israel.
Afiliação
  • Fernandes ADS; Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
  • de Oliveira CG; Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
  • Evangelista H; Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
  • Sulamita D S M; Plant Biology Department, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
  • Araujo-Lima CF; Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
  • Felzenszwalb I; Laboratory of Molecular Biology, Federal University of the Rio de Janeiro State, Rio de Janeiro, Brazil.
Mutagenesis ; 39(1): 56-68, 2024 Feb 08.
Article em En | MEDLINE | ID: mdl-37776161
Several bioactive compounds, such as polyphenols, demonstrate low toxicity and prominent effects on cancer cells with antioxidant, anti-inflammatory, and antitumor activities. Such compounds can be found in Amazon mosses Leucobryum martianum (Hornsch.) Hampe ex Müll. Hal. (Hornsch.) and Leucobryum laevifolium (Broth). Antimutagenic assay with Salmonella enterica serovar Typhimurium and cytotoxicity with different eukaryotic cell lines were carried out to screen aqueous, hydroalcoholic, and ethanolic extracts of those Amazon mosses for anticancer potential. The results indicate the capacity of all extracts of both mosses to exert chemopreventive effects against 4-nitroquinoline-N-oxide (4NQO) and 2-aminoanthracene (2-AA), which are direct or indirect mutagens. In particular, the ethanolic and aqueous extract from L. martianum. The ethanolic extract from L. martianum induces significant cytotoxicity by mitochondrial metabolism and cell membrane disruption pathways to tumor or non-tumor cells. The aqueous extract from L. martianum showed a mainly cytotoxic response in the HepG2 cells, a human liver carcinoma, reaching ~90% cytotoxicity. The same extract did not induce significant damage to normal liver cells (F C3H cells) by membrane interaction pathway. The selective cytotoxicity in the aqueous extract of L. martianum makes it a candidate against liver cancer. Further studies, including in vivo models, are necessary to validate the efficacy and safety of the aqueous extract of L. martianum.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antimutagênicos / Briófitas / Antineoplásicos Limite: Humans Idioma: En Revista: Mutagenesis Assunto da revista: GENETICA MEDICA / SAUDE AMBIENTAL Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antimutagênicos / Briófitas / Antineoplásicos Limite: Humans Idioma: En Revista: Mutagenesis Assunto da revista: GENETICA MEDICA / SAUDE AMBIENTAL Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido