Your browser doesn't support javascript.
loading
Side effects of different head and neck radiotherapy doses on wistar rat's behavior.
Guerrero, Gustavo Guimarães; Minhoto, Giovanna Bignoto; Tibúrcio-Machado, Camilla Dos Santos; Pinto, Itza Amarisis Ribeiro; Federico, Claudio Antonio; Valera, Marcia Carneiro.
Afiliação
  • Guerrero GG; Department of Restorative Dentistry, Endodontic Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil.
  • Minhoto GB; Department of Restorative Dentistry, Endodontic Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil.
  • Tibúrcio-Machado CDS; Department of Restorative Dentistry, Endodontic Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil.
  • Pinto IAR; Department of Restorative Dentistry, Endodontic Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil.
  • Federico CA; IEAv - Institute for Advanced Studies, São José dos Campos, São Paulo, Brazil.
  • Valera MC; Department of Restorative Dentistry, Endodontic Division, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil. Electronic address: marcia.valera@unesp.br.
Brain Res ; 1822: 148606, 2024 01 01.
Article em En | MEDLINE | ID: mdl-37769894
ABSTRACT
Radiotherapy (RT) is a common treatment for head and neck tumors. However, it causes several physical and behavioral side effects, and no study has assessed the emotional effects in rats. Therefore, the present study evaluated the influence of head and neck RT on the behavior and body weight gain in Wistar rats. Fifty-four male Wistar rats were allocated into six groups (n = 9) according to the irradiation dose, which was applied at the first day of the experiment RT-7.5 (single dose of 7.5 Gy); RT-10 (single dose of 10 Gy); RT-15 (single dose of 15 Gy); RT-30 (single dose of 30 Gy); Control (without RT). The animals were irradiated in the region of the right face, and behavioral tests and weighing were performed on days one, seven, and 28. The open field and Y-maze tests were undertaken to analyze the animal's behavior. The dose of 30 Gy was lethal when applied to the head and neck region. The irradiated animals had less weight gain when compared to the control ones, but there was no statistical difference. In the open field and Y-maze tests, lower mobility of animals in the RT groups was observed both on day seven and at the end of the experiment (day 28) when compared to the control rats (p < 0.05). It was possible to conclude that the different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups, however, without statistical difference.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Cabeça e Pescoço Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Cabeça e Pescoço Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda