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Serum levels and gestational curve of adiponectin and leptin during adolescent pregnancy.
Baratto, Indiomara; Daher, Silvia; Fernandes, Mirela Douradinho; Lobo, Thalita Frutuoso; Pendeloski, Karen Priscilla Tezotto; Araujo Júnior, Edward; Guazzelli, Cristina Aparecida Falbo.
Afiliação
  • Baratto I; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
  • Daher S; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
  • Fernandes MD; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
  • Lobo TF; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
  • Pendeloski KPT; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
  • Araujo Júnior E; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
  • Guazzelli CAF; Universidade Federal de São Paulo, Paulista School of Medicine, Department of Obstetrics - São Paulo (SP), Brazil.
Rev Assoc Med Bras (1992) ; 69(9): e20230077, 2023.
Article em En | MEDLINE | ID: mdl-37729356
OBJECTIVE: This study aimed to develop a curve of weekly serum levels of adiponectin and leptin among pregnant adolescents. In addition, pregestational body mass index and weight gain were assessed and correlated with the serum concentration of these molecules. METHODS: This was a prospective cohort study, including only pregnant adolescents with eutrophic pre-gestational body mass index who were weekly followed during the evolution of gestation. The serum concentrations of adipokines were determined using commercial ELISA kits and were correlated to pre-gestational body mass index and pregnancy weight gain. A total of 157 pregnant women participated in this study. RESULTS: Adiponectin levels showed a significant decrease among the trimesters (p=0.0004). However, we did not observe significant differences among its levels when compared weekly, neither of which was between adiponectin concentration and pre-gestational body mass index or weight gain (p=0.36 and p=0.10, respectively). In contrast, we detected a significant increase in weekly serum leptin levels (p<0.0001), positively correlated to both pre-gestational body mass index and weight gain (p=0.003 and p=0.0007, respectively). CONCLUSION: These adipokines present a different profile throughout adolescent pregnancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gravidez na Adolescência / Leptina Tipo de estudo: Observational_studies Limite: Adolescent / Female / Humans / Pregnancy Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gravidez na Adolescência / Leptina Tipo de estudo: Observational_studies Limite: Adolescent / Female / Humans / Pregnancy Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil