Your browser doesn't support javascript.
loading
Risk factors for death and illness severity in vaccinated versus unvaccinated COVID-2019 inpatients: a retrospective cohort study.
Costa, Guilherme Jorge; Silva Junior, José Roberto da; Silva, Caio Cesar Arruda da; Lima, Tiago Pessoa Ferreira de; Costa, Mariana Menezes; Sousa, Marcos Henrique Oliveira; Costa, Gabriela Carla Dos Santos; Costa Júnior, José Iran; Sales, Mozart Júlio Tabosa.
Afiliação
  • Costa GJ; . Departamento de Ensino e Pesquisa, Hospital Alfa, Recife (PE) Brasil.
  • Silva Junior JRD; . Departamento de Ensino e Pesquisa, Instituto de Medicina Integral Professor Fernando Figueira - IMIP - Recife (PE) Brasil.
  • Silva CCAD; . Departamento de Ensino e Pesquisa, Instituto de Medicina Integral Professor Fernando Figueira - IMIP - Recife (PE) Brasil.
  • Lima TPF; . Instituto Federal de Pernambuco - IFPE - Palmares (PE) Brasil.
  • Costa MM; . Departamento de Ensino e Pesquisa, Instituto de Medicina Integral Professor Fernando Figueira - IMIP - Recife (PE) Brasil.
  • Sousa MHO; . Departamento de Ensino e Pesquisa, Instituto de Medicina Integral Professor Fernando Figueira - IMIP - Recife (PE) Brasil.
  • Costa GCDS; . Departamento de Ensino e Pesquisa, Hospital Alfa, Recife (PE) Brasil.
  • Costa Júnior JI; . Departamento de Ensino e Pesquisa, Hospital Alfa, Recife (PE) Brasil.
  • Sales MJT; . Departamento de Ensino e Pesquisa, Instituto de Medicina Integral Professor Fernando Figueira - IMIP - Recife (PE) Brasil.
J Bras Pneumol ; 49(4): e20230145, 2023.
Article em En, Pt | MEDLINE | ID: mdl-37729337
OBJECTIVE: To determine the clinical profile of COVID-19 inpatients who were vaccinated prior to hospitalization and to compare the risk factors for death and the 28-day survival rate of between those inpatients vaccinated with one, two, or three doses and unvaccinated COVID-19 inpatients. METHODS: This was a retrospective observational cohort study involving COVID-19 patients admitted to a referral hospital in the city of Recife, Brazil, between July of 2020 and June of 2022. RESULTS: The sample comprised 1,921 inpatients, 996 of whom (50.8%) were vaccinated prior to hospitalization. After adjusting the mortality risk for vaccinated patients, those undergoing invasive mechanical ventilation (IMV) had the highest mortality risk (adjusted OR [aOR] = 7.4; 95% CI, 3.8-14.1; p < 0.001), followed by patients > 80 years of age (aOR = 7.3; 95% CI, 3.4-15.4; p < 0.001), and those needing vasopressors (aOR = 5.6; 95% CI, 2.9-10.9; p < 0.001). After adjusting the mortality risk for all patients, having received three vaccine doses (aOR = 0.06; 95% CI, 0.03-0.11; p < 0.001) was the most important protective factor against death. There were progressive benefits of vaccination, reducing the frequency of ICU admissions, use for IMV, and death (respectively, from 44.9%, 39.0% and 39.9% after the first dose to 16.7%, 6.2% and 4.4% after the third dose), as well as significant improvements in survival after each subsequent dose (p < 0.001). CONCLUSIONS: Vaccines were effective in reducing illness severity and death in this cohort of COVID-19 inpatients, and the administration of additional doses conferred them with accumulative vaccine protection.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Pacientes Internados Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Humans Idioma: En / Pt Revista: J Bras Pneumol Ano de publicação: 2023 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Pacientes Internados Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Humans Idioma: En / Pt Revista: J Bras Pneumol Ano de publicação: 2023 Tipo de documento: Article País de publicação: Brasil