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Pythium insidiosum: insights into biofilm formation and antibiofilm activity of antifungal drugs.
Pippi, B; Loreto, E S; Merkel, S; Joaquim, A R; Krummenauer, M E; Reginatto, P; Vainstein, M H; Andrade, S F; Fuentefria, A M; Santurio, J M; Zanette, R A.
Afiliação
  • Pippi B; Graduation Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
  • Loreto ES; Sobresp Faculty of Health Sciences, Santa Maria, RS, Brazil.
  • Merkel S; Graduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil.
  • Joaquim AR; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Krummenauer ME; Biotechnology Center, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Reginatto P; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Vainstein MH; Biotechnology Center, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Andrade SF; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Fuentefria AM; Graduation Program in Biological Sciences: Pharmacology and Therapeutics, Department of Pharmacology, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, 2600 Ramiro Barcelos Street, Porto Alegre, RS, 90035-003, Brazil.
  • Santurio JM; Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil.
  • Zanette RA; Graduation Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Braz J Microbiol ; 54(4): 2603-2607, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37702922
In this study, we investigate the ability of Pythium insidiosum to form biofilms across various substrates and the antibiofilm efficacy of 8-hydroxyquinoline derivatives (8-HQs). Biofilms of P. insidiosum were cultured on polystyrene plates, contact lenses, and horsehair. We provide the first evidence of P. insidiosum's biofilm-forming capability, thus considerably expanding our understanding of its transmission and pathogenesis. Our results demonstrate that 8-HQs effectively inhibit biofilm formation and eradicate pre-existing biofilms, underscoring their potential as a novel treatment strategy for pythiosis, a disease currently lacking a gold-standard treatment. This finding has particular relevance for ocular pythiosis associated with contact lens usage and potential infection sources in animals. Our results contribute to the scientific knowledge base and directly impact innovative therapeutic interventions' development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pythium / Pitiose Limite: Animals Idioma: En Revista: Braz J Microbiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pythium / Pitiose Limite: Animals Idioma: En Revista: Braz J Microbiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil