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Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos, Wanessa Maria; Rogerio, Alexandre Paula.
Afiliação
  • Dos Santos WM; Departamento de Biomedicina, Laboratory of Experimental Immunopharmacology, Universidade Federal of Triângulo Mineiro, Rua Manoel Carlos, 162. 38025-380, Uberaba, MG, Brazil.
  • Rogerio AP; Departamento de Biomedicina, Laboratory of Experimental Immunopharmacology, Universidade Federal of Triângulo Mineiro, Rua Manoel Carlos, 162. 38025-380, Uberaba, MG, Brazil.
Article em En | MEDLINE | ID: mdl-37702231
Cryptococcus neoformans and C. gattii pneumonitis could persist asymptomatically for indefinite periods, resolve, or progress to symptomatic dissemination, mainly in immunocompromised individuals (e.g., treated with corticosteroids). The symptoms of COVID-19 may range from a self-limiting illness with general symptoms, such as fever, to more severe complications, such as pneumonitis. The glucocorticoids emerged as potential for treatment of COVID-19, mainly those patients who required ventilator therapy. However, although treatment with glucocorticoids has shown benefits in patients with COVID-19, they can be dangerous due to increased risk of coinfections and superinfections caused by opportunistic pathogens such as Cryptococcus ssp. Some patients with severe COVID-19 pneumonia treated with glucocorticoids developed cryptococcal infection and died. Therefore, immunomodulatory therapy could increase the susceptibility to acute infection or reactivation of Cryptococcus ssp in COVID-19 patients, and this could be complicated once pulmonary cryptococcosis has symptoms similar to COVID-19 becomes difficult to distinguish between the two disease states and treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criptococose / Cryptococcus neoformans / Cryptococcus gattii / COVID-19 Limite: Humans Idioma: En Revista: Antiinflamm Antiallergy Agents Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criptococose / Cryptococcus neoformans / Cryptococcus gattii / COVID-19 Limite: Humans Idioma: En Revista: Antiinflamm Antiallergy Agents Med Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Emirados Árabes Unidos