Integrated transcriptome and proteome analysis indicates potential biomarkers of prostate cancer in offspring of pregnant rats exposed to a phthalate mixture during gestation and lactation.

Aquino, A M; Alonso-Costa, L G; Santos, S A A; Rocha, V A; Barbisan, L F; Bedrat, A; Justulin, L A; Flaws, J A; Lemos, B; Scarano, W R

Aquino, A M; Alonso-Costa, L G; Santos, S A A; Rocha, V A; Barbisan, L F; Bedrat, A; Justulin, L A; Flaws, J A; Lemos, B; Scarano, W R.

Afiliação

Aquino AM; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Alonso-Costa LG; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Santos SAA; Cancer Signaling and Epigenetics, Fox Chase Cancer Center, Philadelphia, USA.
Rocha VA; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Barbisan LF; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Bedrat A; Harvard T. H. Chan School of Public Health, Department of Environmental Health & Molecular and Integrative Physiological Sciences Program, Boston, Massachussets, USA.
Justulin LA; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Flaws JA; Department of Comparative Biosciences; University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Lemos B; Harvard T. H. Chan School of Public Health, Department of Environmental Health & Molecular and Integrative Physiological Sciences Program, Boston, Massachussets, USA.
Scarano WR; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. Electronic address: wellerson.scarano@unesp.br.

Chemosphere ; 341: 140020, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37690569

Assuntos

Neoplasias da Próstata; Proteoma; Animais; Humanos; Masculino; Gravidez; Ratos; Biomarcadores; Lactação; Neoplasias da Próstata/induzido quimicamente; Neoplasias da Próstata/genética; Transcriptoma; Feminino; Exposição Materna/efeitos adversos

Palavras-chave

DOHaD; Maternal exposure; Offspring; Phthalate mixture; Prostate; Proteome; mRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Proteoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Chemosphere Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

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