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Progressive strength training can reverse sarcopenia stage in middle-aged and older adults regardless of their genetic profile.
Silva, Ana C da; Mapa, Vinícius; Ferreira-Júnior, João B; Oliveira, Emerson C de; Becker, Lenice K; Rosse, Izinara; Coelho, Daniel B.
Afiliação
  • Silva ACD; Postgraduate Program in Health and Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
  • Mapa V; Postgraduate Program in Health and Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
  • Ferreira-Júnior JB; Department of Physical Education, Federal Institute of Southeast Minas Gerais - Campus Rio Pomba, Rio Pomba, Minas Gerais, Brazil.
  • Oliveira EC; Federal University of Ouro Preto, School of Physical Education and Postgraduate Program in Health and Nutrition, Ouro Preto, Minas Gerais, Brazil.
  • Becker LK; Federal University of Ouro Preto, School of Physical Education and Postgraduate Program in Health and Nutrition, Ouro Preto, Minas Gerais, Brazil.
  • Rosse I; Federal University of Ouro Preto, School of Pharmacy, Ouro Preto, Minas Gerais, Brazil.
  • Coelho DB; Federal University of Ouro Preto, School of Physical Education and Postgraduate Program in Health and Nutrition, Ouro Preto, Minas Gerais, Brazil. Electronic address: daniel@ufop.edu.br.
Arch Gerontol Geriatr ; 117: 105182, 2024 02.
Article em En | MEDLINE | ID: mdl-37688919
ABSTRACT
The aim of this study was to verify the association of the ACTN3-R577X polymorphism with sarcopenia stage, according to the Revised European Consensus on the Definition and Diagnosis of Sarcopenia, in middle-aged and older adults, pre- and post- ST. In the 12-week longitudinal study, 71 middle-aged and older adults were evaluated; the participants were assigned to either control or intervention group. The intervention group underwent progressive ST three times a week. All participants underwent blood collection, DNA extraction, genotyping of the ACTN3-R577X polymorphism, anthropometric evaluations, and diagnostic tests for sarcopenia. The last two tests were repeated after 12 weeks. No association of the ACTN3-R577X polymorphism with sarcopenia stage was observed before and after 12 weeks. However, the intervention group remained non-sarcopenic (n = 25, p <0.05) or achieved changes in sarcopenia stage (from sarcopenic to non-sarcopenic) (n = 13, p <0.05). Our study demonstrates that progressive ST performed regularly can reverse or prevent sarcopenia regardless of genotype for the ACTN3-R577X polymorphism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treinamento Resistido / Sarcopenia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Arch Gerontol Geriatr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treinamento Resistido / Sarcopenia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Arch Gerontol Geriatr Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda