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Evaluation of a Standardized Extract Obtained from Cashew Apple (Anacardium occidentale L.) Bagasse in DSS-Induced Mouse Colitis.
da Silva, Gisele Goulart; Braga, Lucia Elaine de Oliveira; de Oliveira, Ellen Cristina Souza; de Carvalho, João Ernesto; Lazarini, Josy Goldoni; Rosalen, Pedro Luiz; Dionísio, Ana Paula; Ruiz, Ana Lucia Tasca Gois.
Afiliação
  • da Silva GG; Piracicaba Dental School, Graduate Program in Dentistry, University of Campinas, UNICAMP, Piracicaba 13414-903, SP, Brazil.
  • Braga LEO; Piracicaba Dental School, Graduate Program in Dentistry, University of Campinas, UNICAMP, Piracicaba 13414-903, SP, Brazil.
  • de Oliveira ECS; Institute of Biology, Cellular and Structural Biology Graduate Program, University of Campinas, UNICAMP, Campinas 13083-865, SP, Brazil.
  • de Carvalho JE; Faculty of Pharmaceutical Sciences, University of Campinas, UNICAMP, Campinas 13083-871, SP, Brazil.
  • Lazarini JG; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, UNICAMP, Piracicaba 13414-903, SP, Brazil.
  • Rosalen PL; Faculty of Medicine, Universidade Anhembi Morumbi, Piracicaba 13425-380, SP, Brazil.
  • Dionísio AP; Piracicaba Dental School, Graduate Program in Dentistry, University of Campinas, UNICAMP, Piracicaba 13414-903, SP, Brazil.
  • Ruiz ALTG; Biological Sciences Graduate Program, Federal University of Alfenas, UNIFAL-MG, Alfenas 37130-001, MG, Brazil.
Foods ; 12(17)2023 Sep 04.
Article em En | MEDLINE | ID: mdl-37685250
Inflammatory bowel diseases (IBD) include Crohn's disease and ulcerative colitis. Several studies relate eating habits to different aspects of IBD, such as progression and worsening of the clinical condition. Therefore, many natural products (NPs) such as polyphenols and carotenoids have been identified as promising agents in supporting IBD. An interesting source for obtaining bioactive NPs is the by-products of the food industry. The present study evaluated the potential beneficial effect of a standardized extract (CAE) obtained from cashew apple bagasse in the dextran sulfate sodium (DSS)-induced ulcerative colitis model in mice. This was the first time that CAE had been evaluated in this experimental model. Chemical evaluation of CAE identified carotenoids (96.28 ± 0.15 mg/100 g), phenolic compounds (37.49 ± 0.64 mg/100 g), and a mixture of anacardic acids (C15:3 = 94.2 ± 0.6 mg/100 g; C15:2 = 108.4 ± 0.1 mg/100 g; C15:1 = 214.8 ± 0.2 mg/100 g). Administration of CAE (500 mg/kg, 4 days, p.o.) after DSS challenge was more effective in delaying disease progression compared with prior treatment (500 mg/kg, 30 days, p.o.), according to the disease activity index. However, no treatment strategy with CAE was able to prevent or inhibit disease progression, since all parameters evaluated (macroscopic, biochemical, and histopathological) in CAE-treated animals were similar to those observed in DSS-challenged animals. Despite the high dose (500 mg/kg), the standardized extract (CAE) did not result in an effective concentration of carotenoids. Furthermore, as some anacardic acids have been reported as histone acetyltransferases inhibitors, there could be a possible antagonistic relationship between carotenoids and anacardic acids. Complementary research will be necessary to test the hypothesis of antagonism. Thus, an optimized extract, with an even higher concentration of carotenoids, obtained from cashew apple bagasse, can be developed as a possible adjuvant food supplement for inflammatory bowel diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Foods Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Foods Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça