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Impaired proliferation and migration of HUVEC and melanoma cells by human anti-FGF2 mAbs derived from a murine hybridoma by guided selection.
Georg Magalhães, Carolina; Ploeger Mansueli, Carla; Manieri, Tânia Maria; Quintilio, Wagner; Garbuio, Angélica; de Jesus Marinho, Juan; de Moraes, Jane Zveiter; Tsuruta, Lilian Rumi; Moro, Ana Maria.
Afiliação
  • Georg Magalhães C; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • Ploeger Mansueli C; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • Manieri TM; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • Quintilio W; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • Garbuio A; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • de Jesus Marinho J; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • de Moraes JZ; Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Tsuruta LR; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
  • Moro AM; Laboratory of Biopharmaceuticals, Butantan Institute, São Paulo, Brazil.
Bioengineered ; 14(1): 2252667, 2023 12.
Article em En | MEDLINE | ID: mdl-37661761
The guided selection humanization process enabled the production of 20 human mAbs anti-FGF2;Seven human anti-FGF2 mAbs showed binding to the rFGF2 antigen in the SPR binding assay;Two human anti-FGF2 mAbs inhibited the proliferation and migration of HUVEC and SK-Mel-28 cells and were predicted to contact the FGF2 at a similar patch of residues than the original mAb.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioengineered Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Bioengineered Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos