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Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization.
Usuda, Júlia Nakanishi; Plaça, Desirée Rodrigues; Fonseca, Dennyson Leandro M; Marques, Alexandre H C; Filgueiras, Igor Salerno; Chaves, Victor Gabriel Bastos; Adri, Anny Silva; Torrentes-Carvalho, Amanda; Hirata, Mario Hiroyuki; Freire, Paula Paccielli; Catar, Rusan; Cabral-Miranda, Gustavo; Schimke, Lena F; Moll, Guido; Cabral-Marques, Otavio.
Afiliação
  • Usuda JN; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Plaça DR; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Fonseca DLM; Interunit PostGraduate Program on Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil.
  • Marques AHC; Departament of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Filgueiras IS; Departament of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Chaves VGB; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Adri AS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Torrentes-Carvalho A; Departament of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.
  • Hirata MH; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Freire PP; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Catar R; Departament of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Cabral-Miranda G; Departament of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany.
  • Schimke LF; Departament of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Moll G; Departament of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Cabral-Marques O; Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.
Front Immunol ; 14: 1243516, 2023.
Article em En | MEDLINE | ID: mdl-37638052
Dengue virus (DENV) infection manifests as a febrile illness with three distinct phases: early acute, late acute, and convalescent. Dengue can result in clinical manifestations with different degrees of severity, dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Interferons (IFNs) are antiviral cytokines central to the anti-DENV immune response. Notably, the distinct global signature of type I, II, and III interferon-regulated genes (the interferome) remains uncharacterized in dengue patients to date. Therefore, we performed an in-depth cross-study for the integrative analysis of transcriptome data related to DENV infection. Our systems biology analysis shows that the anti-dengue immune response is characterized by the modulation of numerous interferon-regulated genes (IRGs) enriching, for instance, cytokine-mediated signaling (e.g., type I and II IFNs) and chemotaxis, which is then followed by a transcriptional wave of genes associated with cell cycle, also regulated by the IFN cascade. The adjunct analysis of disease stratification potential, followed by a transcriptional meta-analysis of the interferome, indicated genes such as IFI27, ISG15, and CYBRD1 as potential suitable biomarkers of disease severity. Thus, this study characterizes the landscape of the interferome signature in DENV infection, indicating that interferome dynamics are a crucial and central part of the anti-dengue immune response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Biologia de Sistemas Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Biologia de Sistemas Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça