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Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells.
Dourado, Douglas; Batista, Fabiana Pacheco Reis; Philadelpho, Biane Oliveira; de Souza, Myla Lôbo; de Cerqueira E Silva, Mariana Barros; de Grandis, Rone Aparecido; Miranda, Priscila Anjos; Colauto, Nelson Barros; Pereira, Daniel T; Formiga, Fabio Rocha; Cilli, Eduardo Maffud; Pavan, Fernando Rogério; Oliveira de Souza, Carolina; Ferreira, Ederlan de Souza.
Afiliação
  • Dourado D; School of Pharmacy, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Faria Street, Natal 59012-570, RN, Brazil.
  • Batista FPR; Department of Immunology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife 50670-420, PE, Brazil.
  • Philadelpho BO; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil.
  • de Souza ML; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil.
  • de Cerqueira E Silva MB; College of Pharmacy, Federal University of Pernambuco, Professor Artur de Sá Street, Recife 50740-521, PE, Brazil.
  • de Grandis RA; School of Pharmacy, Federal University of Amazonas, General Rodrigo Octávio Jordão Ramos Avenue, Manaus 69067-005, AM, Brazil.
  • Miranda PA; School of Pharmacy, São Paulo State University (UNESP), Araraquara-Jaú Road, Araraquara 148000-903, SP, Brazil.
  • Colauto NB; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil.
  • Pereira DT; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil.
  • Formiga FR; School of Pharmacy, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Faria Street, Natal 59012-570, RN, Brazil.
  • Cilli EM; Department of Immunology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife 50670-420, PE, Brazil.
  • Pavan FR; Institute of Chemistry, São Paulo State University (UNESP), Prof. Francisco Swgni Street, Araraquara 14800-0600, SP, Brazil.
  • Oliveira de Souza C; School of Pharmacy, São Paulo State University (UNESP), Araraquara-Jaú Road, Araraquara 148000-903, SP, Brazil.
  • Ferreira ES; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil.
Int J Mol Sci ; 24(15)2023 Jul 28.
Article em En | MEDLINE | ID: mdl-37569487
This study aimed to evaluate Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 ± 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 µg/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 µg/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cytotoxic against tumor cells at 50 µg/mL. Thus, SON is a potential new platform for the delivery of resveratrol with selective cytotoxic activity in the treatment of melanoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleo de Palmeira / Arecaceae / Resveratrol / Nanogéis / Sistemas de Liberação de Fármacos por Nanopartículas / Melanoma / Antineoplásicos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleo de Palmeira / Arecaceae / Resveratrol / Nanogéis / Sistemas de Liberação de Fármacos por Nanopartículas / Melanoma / Antineoplásicos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça