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MAOA uVNTR Polymorphism Influence on Older Adults Diagnosed with Diabetes Mellitus/Systemic Arterial Hypertension.
Moura Alves Seixas, Gabriel; de Souza Freitas, Renata; Ferreira Fratelli, Caroline; de Souza Silva, Calliandra Maria; Ramos de Lima, Luciano; Morato Stival, Marina; Schwerz Funghetto, Silvana; Rodrigues da Silva, Izabel Cristina.
Afiliação
  • Moura Alves Seixas G; Graduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
  • de Souza Freitas R; University Center of Brasília (UniCEUB), Brasília, Brazil.
  • Ferreira Fratelli C; Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
  • de Souza Silva CM; Graduate Program in Health Sciences and Technologies, Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
  • Ramos de Lima L; Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
  • Morato Stival M; Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
  • Schwerz Funghetto S; Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
  • Rodrigues da Silva IC; Faculty of Ceilândia, University of Brasilia, Federal District, Brasília, Brazil.
J Aging Res ; 2023: 8538027, 2023.
Article em En | MEDLINE | ID: mdl-37533936
Background: Monoamine oxidase (MAO) is involved in several biological processes associated with well-being and mental health, and alterations in its function might directly impact various mental disorders. Some mental disorders concomitantly occur in individuals with clinical characteristics, such as substance abuse and diabetes. Objective: To analyze the functional MAOA uVNTR polymorphism genotype frequency in an older adult population with diabetes mellitus/arterial hypertension and associate this frequency with clinical characteristics impacting daily life. Methodology. Older adults diagnosed with diabetes mellitus, systemic arterial hypertension, or both (DM/SAH) were selected and had their MAOA gene genotyped for uVNTR polymorphism. The revised Beck Depression Inventory (BDI) and a questionnaire were also applied to determine their mental health and clinical characteristics. Results: The allelic variants detected among the participants were the 2R, 3R, 4R, and 3R/4R heterozygous genotypes. Genotypes solely containing the 3R allele had patients who marked yes for smoking and alcoholism, and only those with the 3R genotypes (female 3R/3R homozygote or male 3R∗ hemizygote) were significant. Although not statistically significant, only 3R and 3R/4R genotypes presented cases of severe depression per the revised BDI interpretations. Conclusion: The MAOA uVNTR polymorphism's low-activity 3R allele presence in an older adult population diagnosed with DM/SAH may represent a risk for developing substance use (alcohol and smoking) dependence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: J Aging Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: J Aging Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos