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MMP11 and MMP17 are potential biomarkers for uterine corpus endometrial carcinoma prognosis.
Zhang, Yanhui; Wang, Jing; Fan, Yuqin; Lang, Fangfang; Fu, Fengping; Liu, Qunying.
Afiliação
  • Zhang Y; Shandong Province Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Jinan City, Shandong Province, China.
  • Wang J; Shandong Province Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Jinan City, Shandong Province, China.
  • Fan Y; Shandong Province Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Jinan City, Shandong Province, China.
  • Lang F; Shandong Province Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Jinan City, Shandong Province, China.
  • Fu F; Shandong Province Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Jinan City, Shandong Province, China.
  • Liu Q; Shandong Province Maternal and Child Health Care Hospital Affiliated to Qingdao University, No. 238, Jingshi East Road, Jinan City, Shandong Province, China. fylzc2021@163.com.
Clin Transl Oncol ; 26(3): 653-663, 2024 Mar.
Article em En | MEDLINE | ID: mdl-37523078
BACKGROUND: Matrix metalloproteinases (MMP) are important proteases that degrade the extracellular matrix (ECM) and thus essentially mediate tumor vascularization, metastasis, and invasion. However, their potential roles in uterine corpus endometrial carcinoma (UCEC) are not fully understood. PATIENTS AND METHODS: The expression, prognostic value, and correlation of UCEC patients with MMP were investigated using data from The Cancer Genome Atlas (TCGA) and other databases. Furthermore, differentially expressed genes (DEGs) were identified and their biological functions and correlations with infiltrating immune cells were analyzed. RESULTS: A total of 22 MMPs were found to be abnormally expressed in UCEC tumor tissues, and high expression of MMP11 and MMP17 were associated with a better UCEC prognosis. MMP11 and MMP17 were observed to be significantly enriched in tumor tissue ECM and were associated with pathways involving degradation, glycolytic metabolism, and PI3K-Akt signaling. Infiltration of natural killer (NK), mast, and NK CD56bright cells was enhanced in tumor tissues with high MMP11 and MMP17 expression. CONCLUSION: MMP11 and MMP17 may affect UCEC prognosis by influencing immune cell infiltration and may be potential UCEC biomarkers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide / Metaloproteinase 17 da Matriz Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Itália
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Carcinoma Endometrioide / Metaloproteinase 17 da Matriz Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Itália