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Are trajectories of depressive symptoms during the first half of drug-sensitive pulmonary tuberculosis treatment associated with loss to follow-up? A secondary analysis of longitudinal data.
Ruiz-Grosso, Paulo; Loret de Mola, Christian; Otero, Larissa; Ugarte-Gil, Cesar.
Afiliação
  • Ruiz-Grosso P; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, San Martín de Porres, Lima, Peru paulo.ruiz@upch.pe.
  • Loret de Mola C; Programa de Control de Tuberculosis, Dirección de Redes Integradas de Salud Lima Norte, Estado Peruano Ministerio de Salud, Lima, Peru.
  • Otero L; GPIS Grupo de Pesquisa e Inovação em Saúde, Universidade Federal do Rio Grande, Rio Grande, Brazil.
  • Ugarte-Gil C; Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, San Martín de Porres, Lima, Peru.
BMJ Open ; 13(7): e068235, 2023 07 19.
Article em En | MEDLINE | ID: mdl-37474177
OBJECTIVE: The objective of this study was to identify trajectories of depressive symptoms (DSs) during the first half of drug-sensitive pulmonary tuberculosis (PTB) treatment and examine their association with loss to follow-up (LTFU) in the second half. DESIGN: This study involved a secondary analysis of longitudinal data to identify potential trajectories of DS and their relationship with LTFU. SETTING: The study was conducted in first and second-level health centres located in San Juan de Lurigancho, Lima, Peru. PARTICIPANTS: Anonymised data from 265 individuals, including monthly measures of DSs from diagnosis to the completion of treatment, initiation of treatment for multidrug resistant TB, LTFU or death, were collected. RESULTS: Three trajectories were identified: 'declining', 'growth' and 'high'. These trajectories were observed in 182 (68.7%), 53 (20%) and 30 (11.3%) of the 265 individuals, respectively, during the first half of PTB treatment. Compared with those with a 'declining' trajectory, individuals with a 'growth' trajectory had a higher likelihood of experiencing LTFU during the second half of PTB treatment, after controlling for sociodemographic factors and at least weekly alcohol use (OR 3.9; 95% CI 1.09 to 13.97, p=0.036). CONCLUSIONS: The findings suggest that a trajectory of increasing DSs during the first half of PTB treatment is associated with a higher risk of LTFU during the second half.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Depressão Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Peru Idioma: En Revista: BMJ Open Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Peru País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Depressão Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do sul / Peru Idioma: En Revista: BMJ Open Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Peru País de publicação: Reino Unido