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Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas.
Savli, Tugce Bolme; Pasaoglu, Husniye Esra; Savli, Taha Cumhan; Muhammedoglu, Ali; Tokocin, Merve; Öztürk, Çigdem.
Afiliação
  • Savli TB; Gaziantep Cengiz Gokcek Maternity and Child Health Hospital, Department of Pathology - Gaziantep, Turkey.
  • Pasaoglu HE; Istanbul Bagcilar Training and Research Hospital, Department of Pathology - Istanbul, Turkey.
  • Savli TC; Medipol Mega University Hospital, Department of Pathology - Istanbul, Turkey.
  • Muhammedoglu A; Istanbul Bagcilar Training and Research Hospital, Department of Pathology - Istanbul, Turkey.
  • Tokocin M; Istanbul Bagcilar Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.
  • Öztürk Ç; Recep Tayyip Erdogan University Training and Research Hospital, Pathology Department - Rize, Turkey.
Rev Assoc Med Bras (1992) ; 69(7): e20230371, 2023.
Article em En | MEDLINE | ID: mdl-37466609
OBJECTIVE: The expression of cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44 in the area of tumor budding was investigated in breast carcinomas in our study. METHODS: Tumor budding was counted at the invasive margins in 179 breast carcinomas. To understand the microenvironment of tumor budding, we examined the expression status of the immune checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44. RESULTS: Tumors were separated into low (≤5) and high tumor budding groups (>5) based on the median budding number. Lymphovascular, perineural invasion, and the number of metastatic lymph nodes were significantly higher in high-grade budding tumors (p=0.001, p<0.001, and p=0.019, respectively). Tumor-infiltrating lymphocytes were significantly higher in tumors without tumor buddings (p<0.001). When the number of budding increases by one unit, overall survival decreases by 1.07 times (p=0.013). Also, it increases the risk of progression by 1.06 times (p=0.048). In high tumor budding groups, the cytotoxic T lymphocyte-associated antigen 4 staining percentage of lymphocytes was significantly higher (p=0.026). With each increase in the number of buds, an increase in the percentage of cytotoxic T lymphocyte-associated antigen 4 staining was seen in lymphocytes in the microenvironment of TB (p=0.034). CONCLUSION: Tumor budding could predict poor prognosis in breast carcinomas, and anti-cytotoxic T lymphocyte-associated antigen 4 immunotherapies may be beneficial in patients with high tumor budding tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil