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Protective effect of Mucuna pruriens (L.) DC. var. pruriens seed extract on apoptotic germ cells in ethanolic male rats.
Samrid, R; Taoto, C; Wu, A; Sawatpanich, T; Phunchago, N; Uabundit, N; Iamsaard, S.
Afiliação
  • Samrid R; Khon Kaen University, Faculty of Medicine, Department of Anatomy, Khon Kaen, Thailand.
  • Taoto C; Khon Kaen University, Faculty of Medicine, Department of Anatomy, Khon Kaen, Thailand.
  • Wu A; Taipei Medical University, The PhD Program of Translational Medicine, Taipei, Taiwan.
  • Sawatpanich T; Khon Kaen University, Faculty of Medicine, Department of Anatomy, Khon Kaen, Thailand.
  • Phunchago N; Khon Kaen University, Faculty of Medicine, Department of Anatomy, Khon Kaen, Thailand.
  • Uabundit N; Khon Kaen University, Faculty of Medicine, Department of Anatomy, Khon Kaen, Thailand.
  • Iamsaard S; Khon Kaen University, Faculty of Medicine, Department of Anatomy, Khon Kaen, Thailand.
Braz J Biol ; 83: e272629, 2023.
Article em En | MEDLINE | ID: mdl-37436191
Thai Mucuna pruriens (L.) DC. var pruriens (T-MP) seed containing levodopa (L-DOPA) and antioxidant capacity has been shown to improve sexual behavior and male reproductive parameters in rats treated with ethanol (Eth). However, its protective effect on testicular apoptotic germ cells has never been reported. This study aimed to investigate the potential effects of T-MP seed extract on expressions of caspase, proliferating cell nuclear antigen (PCNA), and dopamine D2 receptor (D2R) proteins in Eth rats. Thirty-six male Wistar rats were divided into four groups (9 animals/group), including control, Eth, T-MP150+Eth, and T-MP300+Eth, respectively. Control rats received distilled water, and Eth rats received Eth (3g/kg BW; 40%v/v). The T-MP groups were treated with T-MP seed extract at a dose of 150 or 300 mg/kg before Eth administration for 56 consecutive days. The results showed that the seminiferous tubule diameter and epithelial height were significantly increased in both T-MP treated groups compared to the Eth group. Additionally, the caspase-9 and -3, and PCNA expressions were decreased, but D2R expression was markedly increased in T-MP groups. It was concluded that T-MP seed extract could protect testicular apoptosis induced by Eth via changes in caspase, PCNA, and D2R protein expressions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Mucuna Limite: Animals Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Tailândia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Mucuna Limite: Animals Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Tailândia País de publicação: Brasil