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Short-term strength exercise reduces the macrophage M1/M2 ratio in white adipose tissue of obese animals.
da Costa Fernandes, Célio Junior; da Cruz Rodrigues, Kellen Cristina; de Melo, Diego Gomes; de Campos, Thais Dantis Pereira; Dos Santos Canciglieri, Raphael; Simabuco, Fernando Moreira; da Silva, Adelino Sanchez Ramos; Cintra, Dennys Esper; Ropelle, Eduardo Rochete; Pauli, José Rodrigo; de Moura, Leandro Pereira.
Afiliação
  • da Costa Fernandes CJ; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • da Cruz Rodrigues KC; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • de Melo DG; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • de Campos TDP; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Dos Santos Canciglieri R; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Simabuco FM; Multidisciplinary Laboratory of Food and Health (LABMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil; Department of Biochemistry, Federal University of São Paulo (UNIFESP), Brazil.
  • da Silva ASR; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Cintra DE; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Ropelle ER; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • Pauli JR; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil.
  • de Moura LP; Exercise Cell Biology Lab, School of Applied Sciences, University of Campinas, Limeira, Brazil; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, Brazil. Electronic address: mouralp@unicamp.br.
Life Sci ; 329: 121916, 2023 Sep 15.
Article em En | MEDLINE | ID: mdl-37419412
Obesity can exacerbate the systemic inflammatory process, leading to increased infiltration of monocytes in white adipose tissue (WAT) and polarization of these cells into pro-inflammatory M1 macrophages, while reducing the population of anti-inflammatory M2 macrophages. Aerobic exercise has been shown to be effective in reducing the pro-inflammatory profile. However, the impact of strength training and the duration of training on macrophage polarization in the WAT of obese individuals have not been widely studied. Therefore, our aim was to investigate the effects of resistance exercise on macrophage infiltration and polarization in the epididymal and subcutaneous adipose tissue of obese mice. We compared the following groups: Control (CT), Obese (OB), Obese 7-day strength training (STO7d), and Obese 15-day strength training (STO15d). Macrophage populations were evaluated by flow cytometry: total macrophages (F4/80+), M1 (CD11c), and M2 (CD206) macrophages. Our results demonstrated that both training protocols improved peripheral insulin sensitivity by increasing AKT phosphorylation (Ser473). Specifically, the 7-day training regimen reduced total macrophage infiltration and M2 macrophage levels without altering M1 levels. In the STO15d group, significant differences were observed in total macrophage levels, M1 macrophages, and the M1/M2 ratio compared to the OB group. In the epididymal tissue, a reduction in the M1/M2 ratio was observed in the STO7d group. Overall, our data demonstrate that 15 days of strength exercise can reduce the M1/M2 ratio of macrophages in white adipose tissue.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Tecido Adiposo Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Tecido Adiposo Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda